PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C[C@H]1CC2(CCN(c3ccc(C(=O)N4CCC(CN5CCC6(CCc7ccc(N8CCC(=O)NC8=O)cc7O6)CC5)CC4)cc3)CC2)CN1c1ccc(C#N)c(Cl)c1

Compound summary

Compound IDPGDB_C029719

FormulaC46H54ClN7O4

Molecular weight804.436

InChIKeyVAPPXLVDUDOJAO-YTTGMZPUSA-N

Physicochemical properties

Exact mass803.3926

RDKit cLogP7.26

TPSA112.5

HBD / HBA1 / 8

Rotatable bonds6

Heavy atoms58

Hetero atoms12

Rings / aromatic9 / 3

Fraction Csp30.52

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	41	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A000416	PGDB_C029719	PGDB_AS002389	View
IC50	-	=	0.0000011	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A001080	PGDB_C029719	PGDB_AS000481	View
% Degradation	-	=	92	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A001586	PGDB_C029719	PGDB_AS002389	View
% Degradation	-	=	89	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A002112	PGDB_C029719	PGDB_AS001354	View
IC50	-	=	0.17	nM	-	—	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A002210	PGDB_C029719	PGDB_AS000195	View
% Degradation	-	=	86	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A004472	PGDB_C029719	PGDB_AS002463	View
% Degradation	-	=	55	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A005473	PGDB_C029719	PGDB_AS001838	View
% Degradation	-	=	14	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A005662	PGDB_C029719	PGDB_AS002463	View
IC50	-	=	0.024	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A006376	PGDB_C029719	PGDB_AS000481	View
% Degradation	-	=	26	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A078840	PGDB_C029719	PGDB_AS001354	View
IC50	-	=	0.29	nM	-	—	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A079530	PGDB_C029719	PGDB_AS000195	View
% Degradation	-	=	92	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A080589	PGDB_C029719	PGDB_AS001838	View

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