PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026061104A1

AssigneeGan and Lee Pharmaceuticals Co Ltd

TitleCompound for use in targeted degradation of androgen receptors, and method

Family members1

Filing year2025

Publication date2026-03-26

JurisdictionWO

Compounds416

Activity records2,409

Assays9

Activity compounds and values

Activity records

2,362 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	65	%	100 nM	-	AR	-	LNCaPFGC	PGDB_A000006	PGDB_C029932	PGDB_AS002389	View
% Degradation	-	=	96	%	50 nM	-	AR	-	VCaP	PGDB_A000012	PGDB_C029984	PGDB_AS001838	View
% Degradation	-	=	79	%	50 nM	-	AR	-	VCaP	PGDB_A000013	PGDB_C029769	PGDB_AS001838	View
% Degradation	-	=	70	%	5 nM	-	AR	-	VCaP	PGDB_A000017	PGDB_C029736	PGDB_AS001354	View
IC50	-	=	0.53	nM	-	—	AR	-	LNCaPFGC	PGDB_A000020	PGDB_C029952	PGDB_AS000195	View
% Degradation	-	=	93	%	100 nM	-	AR	-	LNCaPFGC	PGDB_A000025	PGDB_C029736	PGDB_AS002389	View
IC50	-	=	0.0065	nM	-	—	AR	-	VCaP	PGDB_A000029	PGDB_C029789	PGDB_AS000481	View
% Degradation	-	=	81	%	100 nM	-	AR	-	LNCaPFGC	PGDB_A000032	PGDB_C029741	PGDB_AS002389	View
% Degradation	-	=	86	%	100 nM	-	AR	-	LNCaPFGC	PGDB_A000035	PGDB_C029794	PGDB_AS002389	View
% Degradation	-	=	82	%	50 nM	-	AR	-	VCaP	PGDB_A000037	PGDB_C030063	PGDB_AS001838	View
% Degradation	-	=	48	%	10 nM	-	AR	-	LNCaPFGC	PGDB_A000040	PGDB_C029743	PGDB_AS002463	View
% Degradation	-	=	18	%	10 nM	-	AR	-	LNCaPFGC	PGDB_A000042	PGDB_C030080	PGDB_AS002463	View
% Degradation	-	=	75	%	50 nM	-	AR	-	VCaP	PGDB_A000046	PGDB_C029766	PGDB_AS001838	View
% Degradation	-	=	40	%	100 nM	-	AR	-	LNCaPFGC	PGDB_A000049	PGDB_C029959	PGDB_AS002389	View
% Degradation	-	=	90	%	50 nM	-	AR	-	VCaP	PGDB_A000058	PGDB_C029918	PGDB_AS001838	View
% Degradation	-	=	91	%	100 nM	-	AR	-	LNCaPFGC	PGDB_A000060	PGDB_C030130	PGDB_AS002389	View
% Degradation	-	=	90	%	50 nM	-	AR	-	VCaP	PGDB_A000068	PGDB_C029979	PGDB_AS001838	View
% Degradation	-	=	81	%	10 nM	-	AR	-	LNCaPFGC	PGDB_A000070	PGDB_C029979	PGDB_AS002463	View
% Degradation	-	=	79	%	50 nM	-	AR	-	VCaP	PGDB_A000072	PGDB_C030132	PGDB_AS001072	View
% Degradation	-	=	21	%	100 nM	-	AR	-	LNCaPFGC	PGDB_A000073	PGDB_C030116	PGDB_AS002389	View

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