PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C[C@H]1CC2(CCN(c3ccc(C(=O)N4CCC(F)(CN5CCC6(CC5)Oc5ccc(N7CCC(=O)NC7=O)cc5O6)CC4)cc3)CC2)CN1c1ccc(C#N)c(Cl)c1

Compound summary

Compound IDPGDB_C029790

FormulaC44H49ClFN7O5

Molecular weight810.371

InChIKeyCHOMGCMLHBQPEL-PMERELPUSA-N

Physicochemical properties

Exact mass809.3468

RDKit cLogP6.75

TPSA121.7

HBD / HBA1 / 9

Rotatable bonds6

Heavy atoms58

Hetero atoms14

Rings / aromatic9 / 3

Fraction Csp30.5

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	0.075	nM	-	—	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A000436	PGDB_C029790	PGDB_AS000195	View
% Degradation	-	=	70	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A000677	PGDB_C029790	PGDB_AS002463	View
% Degradation	-	=	89	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A003405	PGDB_C029790	PGDB_AS002389	View
IC50	-	=	0.004	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A004953	PGDB_C029790	PGDB_AS000481	View
% Degradation	-	=	82	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A005610	PGDB_C029790	PGDB_AS001354	View
% Degradation	-	=	85	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A006175	PGDB_C029790	PGDB_AS002389	View
IC50	-	=	0.15	nM	-	—	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A078635	PGDB_C029790	PGDB_AS000195	View
% Degradation	-	=	50	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A079301	PGDB_C029790	PGDB_AS001354	View
% Degradation	-	=	26	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A080397	PGDB_C029790	PGDB_AS002463	View
% Degradation	-	=	89	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A080981	PGDB_C029790	PGDB_AS001838	View
IC50	-	=	0.002	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A081239	PGDB_C029790	PGDB_AS000481	View
% Degradation	-	=	94	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A081285	PGDB_C029790	PGDB_AS001838	View

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