PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

COc1cc(O[C@H]2C(C)(C)[C@H](NC(=O)c3ccc(N4CCC(CN5CCN6c7ccc(C8CCC(=O)NC8=O)cc7OCC[C@H]6C5)CC4)c(Cl)c3)C2(C)C)ccc1C#N

Compound summary

Compound IDPGDB_C029863

FormulaC46H55ClN6O6

Molecular weight823.435

InChIKeyDAFVTPBLDIWJDT-NEKMYYAQSA-N

Physicochemical properties

Exact mass822.3872

RDKit cLogP6.54

TPSA136.5

HBD / HBA2 / 10

Rotatable bonds9

Heavy atoms59

Hetero atoms13

Rings / aromatic8 / 3

Fraction Csp30.52

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	72	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A000307	PGDB_C029863	PGDB_AS002389	View
% Degradation	-	=	77	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A001955	PGDB_C029863	PGDB_AS001354	View
IC50	-	=	0.016	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A003477	PGDB_C029863	PGDB_AS000271	View
% Degradation	-	=	31	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A003691	PGDB_C029863	PGDB_AS002463	View
% Degradation	-	=	17	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A004295	PGDB_C029863	PGDB_AS002463	View
% Degradation	-	=	75	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A078552	PGDB_C029863	PGDB_AS002389	View
% Degradation	-	=	79	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A079054	PGDB_C029863	PGDB_AS001838	View
IC50	-	=	1.14	nM	-	—	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A079272	PGDB_C029863	PGDB_AS000195	View
% Degradation	-	=	90	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A079646	PGDB_C029863	PGDB_AS001838	View
IC50	-	=	1.58	nM	-	—	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A080172	PGDB_C029863	PGDB_AS000195	View
IC50	-	=	0.02	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A080780	PGDB_C029863	PGDB_AS000271	View
% Degradation	-	=	35	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A080840	PGDB_C029863	PGDB_AS001354	View

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