PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C[C@H]1CC2(CCN(c3ncc(C(=O)N4CCC(CN5CCN6c7ccc(N8CCC(=O)NC8=O)cc7OCC[C@H]6C5)CC4)cn3)CC2)CN1c1ccc(C#N)c(C(F)(F)F)c1F

Compound summary

Compound IDPGDB_C029952

FormulaC44H50F4N10O4

Molecular weight858.942

InChIKeyHOLWFGZHMVHBAE-UVMMSNCQSA-N

Physicochemical properties

Exact mass858.3953

RDKit cLogP5.66

TPSA141.5

HBD / HBA1 / 11

Rotatable bonds6

Heavy atoms62

Hetero atoms18

Rings / aromatic9 / 3

Fraction Csp30.55

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	0.53	nM	-	—	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A000020	PGDB_C029952	PGDB_AS000195	View
% Degradation	-	=	93	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A000821	PGDB_C029952	PGDB_AS002389	View
% Degradation	-	=	88	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A001042	PGDB_C029952	PGDB_AS001354	View
IC50	-	=	0.53	nM	-	—	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A002555	PGDB_C029952	PGDB_AS000195	View
% Degradation	-	=	79	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A002836	PGDB_C029952	PGDB_AS002463	View
% Degradation	-	=	93	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A003865	PGDB_C029952	PGDB_AS002389	View
% Degradation	-	=	92	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A006461	PGDB_C029952	PGDB_AS001838	View
% Degradation	-	=	88	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A006827	PGDB_C029952	PGDB_AS001354	View
% Degradation	-	=	92	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A078580	PGDB_C029952	PGDB_AS001838	View
IC50	-	=	0.006	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A079394	PGDB_C029952	PGDB_AS000271	View
IC50	-	=	0.006	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A079845	PGDB_C029952	PGDB_AS000271	View
% Degradation	-	=	79	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A081778	PGDB_C029952	PGDB_AS002463	View

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