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Compound
PGDB_C030346
11 activity records1 related patents
2D structure
Nc1nnc(-c2ccccc2O)cc1-c1cnn(C2CCC3(CC2)CN(Cc2ccc(C4CCC(=O)NC4=O)c(F)c2)C3)c1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 1-5 | nM | - | — | - | - | H1944 | WO2026061475A1 | PGDB_A001238 | PGDB_C030346 | PGDB_AS001924 | View |
| % Degradation | - | <= | 50 | % | Concentration series: 500 nM, 50 nM | - | SMARCA2 | - | MV-4-11 | WO2026061475A1 | PGDB_A001374 | PGDB_C030346 | PGDB_AS002335 | View |
| IC50 | - | <= | 1 | nM | - | — | - | - | A375 | WO2026061475A1 | PGDB_A006190 | PGDB_C030346 | PGDB_AS002441 | View |
| IC50 | - | = | 5-10 | nM | - | — | - | - | H838 | WO2026061475A1 | PGDB_A077951 | PGDB_C030346 | PGDB_AS000282 | View |
| IC50 | - | = | 500-700 | nM | - | — | - | - | BT549 | WO2026061475A1 | PGDB_A079198 | PGDB_C030346 | PGDB_AS002259 | View |
| % Inhibition | - | = | 30-40 | % | 0.5 uM | - | CRBN | CRBN | - | WO2026061475A1 | PGDB_A079425 | PGDB_C030346 | PGDB_AS000662 | View |
| % Inhibition | - | = | 70-80 | % | 2 uM | - | CRBN | CRBN | - | WO2026061475A1 | PGDB_A079525 | PGDB_C030346 | PGDB_AS001031 | View |
| IC50 | - | = | 10-20 | nM | - | — | - | - | H2126 | WO2026061475A1 | PGDB_A080983 | PGDB_C030346 | PGDB_AS001417 | View |