PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026061475A1

AssigneeGluetacs Therapeutics Shanghai

TitleBifunctional protein degradation agent containing aryl-substituted heteroaryl group and use thereof

Family members1

Filing year2025

Publication date2026-03-26

JurisdictionWO

Compounds330

Activity records1,839

Assays11

Activity compounds and values

Activity records

1,010 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	100-200	nM	-	—	-	-	CFPAC-1	PGDB_A000002	PGDB_C030428	PGDB_AS000179	View
IC50	-	<=	1	nM	-	—	-	-	CFPAC-1	PGDB_A000011	PGDB_C030373	PGDB_AS000179	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	PGDB_A000021	PGDB_C030500	PGDB_AS000662	View
% Inhibition	-	=	20-30	%	0.5 uM	-	CRBN	CRBN	-	PGDB_A000024	PGDB_C030285	PGDB_AS000662	View
IC50	-	=	5-10	nM	-	—	-	-	H838	PGDB_A000045	PGDB_C030278	PGDB_AS000282	View
IC50	-	=	20-30	nM	-	—	-	-	CFPAC-1	PGDB_A000052	PGDB_C030299	PGDB_AS000179	View
% Degradation	-	<=	50	%	Concentration series: 500 nM, 50 nM	-	SMARCA4	-	MV-4-11	PGDB_A000055	PGDB_C030482	PGDB_AS002340	View
IC50	-	=	200-500	nM	-	—	-	-	CFPAC-1	PGDB_A000061	PGDB_C030405	PGDB_AS000179	View
IC50	-	=	200-500	nM	-	—	-	-	A549	PGDB_A000062	PGDB_C030405	PGDB_AS000757	View
% Degradation	-	<=	50	%	Concentration series: 500 nM, 50 nM	-	SMARCA2	-	MV-4-11	PGDB_A000083	PGDB_C030288	PGDB_AS002335	View
% Inhibition	-	=	10-20	%	0.5 uM	-	CRBN	CRBN	-	PGDB_A000084	PGDB_C030485	PGDB_AS000662	View
% Degradation	-	<=	50	%	Concentration series: 500 nM, 50 nM	-	SMARCA4	-	MV-4-11	PGDB_A000088	PGDB_C030603	PGDB_AS002340	View
% Inhibition	-	=	70-80	%	2 uM	-	CRBN	CRBN	-	PGDB_A000095	PGDB_C030393	PGDB_AS001031	View
% Degradation	-	<=	50	%	Concentration series: 500 nM, 50 nM	-	SMARCA2	-	MV-4-11	PGDB_A000097	PGDB_C030300	PGDB_AS002335	View
IC50	-	=	10-20	nM	-	—	-	-	H838	PGDB_A000107	PGDB_C030403	PGDB_AS000282	View
% Degradation	-	<=	50	%	Concentration series: 500 nM, 50 nM	-	SMARCA2	-	MV-4-11	PGDB_A000118	PGDB_C030420	PGDB_AS002335	View
% Degradation	-	<=	50	%	Concentration series: 500 nM, 50 nM	-	SMARCA2	-	MV-4-11	PGDB_A000129	PGDB_C030588	PGDB_AS002335	View
% Degradation	-	<=	50	%	Concentration series: 500 nM, 50 nM	-	SMARCA4	-	MV-4-11	PGDB_A000138	PGDB_C030407	PGDB_AS002340	View
IC50	-	=	200-500	nM	-	—	-	-	CFPAC-1	PGDB_A000155	PGDB_C030392	PGDB_AS000179	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	PGDB_A000164	PGDB_C030542	PGDB_AS000662	View

Rows per pagePage 1 of 51 · 1,010 recordsGo to page