PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberAU2019272751B2

AssigneeCelgene

TitleTreating multiple myeloma and the use of biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1- oxoisoindolin-4-yl)oxy)methyl)benzyl) piperazin-1-yl)-3-fluorobenzonitrile

Family ID68614443

Family members25

Filing year2019

Publication date2024-08-15

JurisdictionAU

Compounds4

Activity records27

Assays10

Activity compounds and values

Activity records

27 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	0.08	nM	-	—	IKZF3	CRBN	OPM-2	PGDB_A007476	PGDB_C005650	PGDB_AS002253	View
IC50	-	=	0.13	nM	-	—	IKZF1	CRBN	OPM-2	PGDB_A008496	PGDB_C005650	PGDB_AS000106	View
IC50	-	>	100	nM	-	—	IKZF1	CRBN	OPM-2	PGDB_A009428	PGDB_C019024	PGDB_AS000106	View
IC50	-	>	100	nM	-	—	IKZF1	CRBN	OPM-2	PGDB_A010160	PGDB_C019024	PGDB_AS001658	View
IC50	-	>	100	nM	-	—	ZFP91	CRBN	OPM-2	PGDB_A012772	PGDB_C019024	PGDB_AS000285	View
IC50	-	=	89	nM	-	—	IKZF3	CRBN	OPM-2	PGDB_A012964	PGDB_C009601	PGDB_AS002253	View
IC50	-	=	0.06	nM	-	—	IKZF3	-	OPM-2	PGDB_A019381	PGDB_C005650	PGDB_AS001698	View
IC50	-	=	0.08	nM	-	—	ZFP91	CRBN	OPM-2	PGDB_A021546	PGDB_C005650	PGDB_AS000285	View
IC50	-	=	0.0059	uM	-	—	IKZF3	CRBN	DF15	PGDB_A023925	PGDB_C005651	PGDB_AS001348	View
IC50	-	>	0.1	uM	-	—	IKZF3	CRBN	DF15	PGDB_A026335	PGDB_C005651	PGDB_AS001313	View
IC50	-	>	100	nM	-	—	IKZF1	CRBN	OPM-2	PGDB_A030612	PGDB_C005650	PGDB_AS001658	View
IC50	-	=	91	nM	-	—	IKZF1	CRBN	OPM-2	PGDB_A031052	PGDB_C009601	PGDB_AS000106	View
IC50	-	=	56	nM	-	—	IKZF3	-	OPM-2	PGDB_A035209	PGDB_C009601	PGDB_AS001698	View
IC50	-	>	100	nM	-	—	IKZF1	CRBN	OPM-2	PGDB_A039396	PGDB_C009601	PGDB_AS001658	View
IC50	-	>	100	nM	-	—	IKZF3	-	OPM-2	PGDB_A040345	PGDB_C019024	PGDB_AS001698	View
IC50	-	>	100	nM	-	—	IKZF1	-	OPM-2	PGDB_A040978	PGDB_C009601	PGDB_AS000771	View
IC50	-	=	0.08	nM	-	—	-	CRBN	OPM-2	PGDB_A044255	PGDB_C005650	PGDB_AS002367	View
IC50	-	>	0.1	uM	-	—	IKZF3	CRBN	DF15	PGDB_A044432	PGDB_C005650	PGDB_AS001313	View
IC50	-	=	0.00045	uM	-	—	IKZF3	CRBN	DF15	PGDB_A048390	PGDB_C005651	PGDB_AS002160	View
IC50	-	=	0.000031	uM	-	—	IKZF3	CRBN	DF15	PGDB_A049649	PGDB_C005650	PGDB_AS002160	View

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