PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

Compound summary

Compound IDPGDB_C009601

FormulaC13H11N3O4

Molecular weight273.248

InChIKeyUVSMNLNDYGZFPF-UHFFFAOYSA-N

Physicochemical properties

Exact mass273.075

RDKit cLogP-0.33

TPSA109.6

HBD / HBA2 / 5

Rotatable bonds1

Heavy atoms20

Hetero atoms7

Rings / aromatic3 / 1

Fraction Csp30.23

Formal charge0

Fragments1

Activity compounds and values

Activity records

42 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	=	0.332	uM	-	—	SALL4	-	HT-1080	WO2023025136A1	PGDB_A008079	PGDB_C009601	PGDB_AS001426	View
IC50	-	=	97-204	nM	-	—	IKZF1	-	NCI-H929	CA3173658A1	PGDB_A009780	PGDB_C009601	PGDB_AS001574	View
IC50	-	=	30	nM	-	—	-	-	MM.1S	WO2023025136A1	PGDB_A011009	PGDB_C009601	PGDB_AS001243	View
IC50	-	=	0.033	uM	-	—	-	-	-	JP6306592B2	PGDB_A011184	PGDB_C009601	PGDB_AS000268	View
Dmax	-	=	69.7	%	Concentration series: 0.316 nM, 10 uM	20 h	SALL4	CRBN	HT-1080	WO2023025136A1	PGDB_A011674	PGDB_C009601	PGDB_AS001792	View
IC50	-	=	89	nM	-	—	IKZF3	CRBN	OPM-2	AU2019272751B2	PGDB_A012964	PGDB_C009601	PGDB_AS002253	View
IC50	-	>	10	uM	-	—	-	-	-	JP6306592B2	PGDB_A016603	PGDB_C009601	PGDB_AS001058	View
% Degradation	-	=	86	%	10 uM	24 h	IKZF1	-	H929	CN116457344A	PGDB_A017527	PGDB_C009601	PGDB_AS001613	View
IC50	-	=	0.047	uM	-	—	-	-	-	JP6306592B2	PGDB_A018109	PGDB_C009601	PGDB_AS001247	View
IC50	-	=	0.059	uM	-	—	-	-	-	JP6306592B2	PGDB_A020999	PGDB_C009601	PGDB_AS000129	View
% Degradation	-	=	87	%	20 uM	24 h	IKZF3	-	H929	CN116457344A	PGDB_A023036	PGDB_C009601	PGDB_AS001985	View
DC50	-	=	0.332	uM	-	—	SALL4	-	HT-1080	EP4393915A1	PGDB_A029325	PGDB_C009601	PGDB_AS000384	View
IC50	-	=	91	nM	-	—	IKZF1	CRBN	OPM-2	AU2019272751B2	PGDB_A031052	PGDB_C009601	PGDB_AS000106	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	WO2022146151A1	PGDB_A034274	PGDB_C009601	PGDB_AS002364	View
IC50	-	=	64.56542290346549	nM	-	—	-	-	-	EP4683934A1	PGDB_A034803	PGDB_C009601	PGDB_AS002416	View
DC50	-	=	0.266	nM	-	—	IKZF1	-	HT-1080	EP4393915A1	PGDB_A035093	PGDB_C009601	PGDB_AS001653	View
IC50	-	=	56	nM	-	—	IKZF3	-	OPM-2	AU2019272751B2	PGDB_A035209	PGDB_C009601	PGDB_AS001698	View
IC50	-	>	100	nM	-	—	IKZF1	CRBN	OPM-2	AU2019272751B2	PGDB_A039396	PGDB_C009601	PGDB_AS001658	View
Dmax	-	=	69.7	%	Concentration context: HiBiT SALL4:_D max (%)	20 h	SALL4	-	HT-1080	EP4393915A1	PGDB_A040020	PGDB_C009601	PGDB_AS001879	View
IC50	-	>	100	nM	-	—	IKZF1	-	OPM-2	AU2019272751B2	PGDB_A040978	PGDB_C009601	PGDB_AS000771	View

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