PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O

Compound summary

Compound IDPGDB_C019024

FormulaC13H13N3O3

Molecular weight259.265

InChIKeyGOTYRUGSSMKFNF-UHFFFAOYSA-N

Physicochemical properties

Exact mass259.0957

RDKit cLogP0.03

TPSA92.5

HBD / HBA2 / 4

Rotatable bonds1

Heavy atoms19

Hetero atoms6

Rings / aromatic3 / 1

Fraction Csp30.31

Formal charge0

Fragments1

Activity compounds and values

Activity records

36 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	>	100	nM	-	—	IKZF1	CRBN	OPM-2	AU2019272751B2	PGDB_A009428	PGDB_C019024	PGDB_AS000106	View
IC50	-	>	100	nM	-	—	IKZF1	CRBN	OPM-2	AU2019272751B2	PGDB_A010160	PGDB_C019024	PGDB_AS001658	View
IC50	-	>	100	nM	-	—	ZFP91	CRBN	OPM-2	AU2019272751B2	PGDB_A012772	PGDB_C019024	PGDB_AS000285	View
IC50	-	=	0.39	uM	-	—	-	-	-	JP6306592B2	PGDB_A014773	PGDB_C019024	PGDB_AS001247	View
IC50	-	>	10	uM	-	—	-	-	-	JP6306592B2	PGDB_A016703	PGDB_C019024	PGDB_AS001058	View
IC50	-	=	23.0691	nM	-	—	-	-	MM.1S	AU2021209727B2	PGDB_A018657	PGDB_C019024	PGDB_AS002370	View
IC50	-	>	10	uM	-	—	-	-	-	JP6306592B2	PGDB_A022550	PGDB_C019024	PGDB_AS001172	View
EC50	-	=	0.000000622	M	-	—	-	-	-	AU2020404956A1	PGDB_A022685	PGDB_C019024	PGDB_AS000822	View
IC50	-	=	0.433	uM	-	—	-	-	H929	CN116457344A	PGDB_A022870	PGDB_C019024	PGDB_AS000797	View
IC50	-	=	23.0691	nM	-	—	-	-	MM.1S	AU2021209727B2	PGDB_A024898	PGDB_C019024	PGDB_AS000954	View
Relative activity	control	=	540	%	-	-	-	-	-	JP6306592B2	PGDB_A025343	PGDB_C019024	PGDB_AS002248	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	WO2022146151A1	PGDB_A026969	PGDB_C019024	PGDB_AS002364	View
Relative activity	control	=	121	%	-	-	-	-	-	JP6306592B2	PGDB_A028750	PGDB_C019024	PGDB_AS001193	View
IC50	-	=	5.19	uM	-	—	CRBN	CRBN	-	US12110292B2	PGDB_A029425	PGDB_C019024	PGDB_AS001311	View
IC50	-	=	0.000000243162	M	-	—	-	-	-	AU2020404956A1	PGDB_A029866	PGDB_C019024	PGDB_AS000835	View
IC50	-	>	10	uM	-	—	-	-	-	JP6306592B2	PGDB_A036339	PGDB_C019024	PGDB_AS002404	View
Ki	-	<	5	uM	-	—	-	-	-	EP4065576A1	PGDB_A037900	PGDB_C019024	PGDB_AS000901	View
IC50	-	=	119.0859	nM	-	—	-	-	MM.1S	AU2021209727B2	PGDB_A038334	PGDB_C019024	PGDB_AS002501	View
IC50	-	>	100	nM	-	—	IKZF3	-	OPM-2	AU2019272751B2	PGDB_A040345	PGDB_C019024	PGDB_AS001698	View
Relative activity	control	=	312	%	-	-	-	-	-	JP6306592B2	PGDB_A040407	PGDB_C019024	PGDB_AS002413	View

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