PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN116457344A

AssigneeCaptor Therapeutics

TitleLow molecular weight protein degradation agent and application thereof

Family ID72193535

Family members11

Filing year2021

Publication date2023-07-18

JurisdictionCN

Compounds53

Activity records140

Assays11

Activity compounds and values

Activity records

140 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Ki	-	<	0.5	uM	-	—	CRBN	CRBN	-	PGDB_A007045	PGDB_C000078	PGDB_AS001592	View
IC50	-	=	0.072	uM	-	—	-	-	H929	PGDB_A007061	PGDB_C008731	PGDB_AS000797	View
IC50	-	<=	0.1	uM	-	—	-	-	KG-1	PGDB_A007287	PGDB_C000077	PGDB_AS000548	View
% Degradation	-	=	33	%	10 uM	24 h	IKZF1	-	H929	PGDB_A007706	PGDB_C000059	PGDB_AS001613	View
IC50	-	>	50	uM	-	—	-	-	H929	PGDB_A007939	PGDB_C000080	PGDB_AS000797	View
IC50	-	=	0.1-1	uM	-	—	-	-	Hep3B	PGDB_A008581	PGDB_C000072	PGDB_AS001471	View
Ki	-	<	0.5	uM	-	—	CRBN	CRBN	-	PGDB_A008863	PGDB_C000052	PGDB_AS001592	View
IC50	-	=	0.1-1	uM	-	—	-	-	Hep3B	PGDB_A010492	PGDB_C000063	PGDB_AS001471	View
IC50	-	>	50	uM	-	—	-	-	H929	PGDB_A011855	PGDB_C000074	PGDB_AS000797	View
Ki	-	<	0.5	uM	-	—	CRBN	CRBN	-	PGDB_A011906	PGDB_C000079	PGDB_AS001592	View
IC50	-	<=	0.1	uM	-	—	-	-	Hep3B	PGDB_A012141	PGDB_C000074	PGDB_AS001471	View
IC50	-	>	50	uM	-	—	-	-	H929	PGDB_A012287	PGDB_C000064	PGDB_AS000797	View
IC50	-	=	1-5	uM	-	—	-	-	KG-1	PGDB_A012637	PGDB_C000065	PGDB_AS000548	View
% Degradation	-	=	50-79	%	1 uM	24 h	GSPT1	-	Hep3B	PGDB_A012672	PGDB_C000054	PGDB_AS000120	View
IC50	-	>	50	uM	-	—	-	-	H929	PGDB_A012953	PGDB_C000075	PGDB_AS000797	View
IC50	-	=	5-50	uM	-	—	-	-	H929	PGDB_A013700	PGDB_C000067	PGDB_AS000797	View
% Degradation	-	=	50-79	%	10 uM	24 h	GSPT1	-	Hep3B	PGDB_A014647	PGDB_C000051	PGDB_AS001312	View
Ki	-	<	0.5	uM	-	—	CRBN	CRBN	-	PGDB_A015704	PGDB_C000100	PGDB_AS001592	View
% Degradation	-	=	86	%	10 uM	24 h	IKZF1	-	H929	PGDB_A017527	PGDB_C009601	PGDB_AS001613	View
% Degradation	-	>	80	%	100 nM	24 h	SALL4	-	Kelly	PGDB_A017554	PGDB_C000063	PGDB_AS001684	View

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