PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1nc2cccc(N)c2c(=O)n1C1CCC(=O)NC1=O

Compound summary

Compound IDPGDB_C008731

FormulaC14H14N4O3

Molecular weight286.291

InChIKeyRSNPAKAFCAAMBH-UHFFFAOYSA-N

Physicochemical properties

Exact mass286.1066

RDKit cLogP0.26

TPSA107.1

HBD / HBA2 / 6

Rotatable bonds1

Heavy atoms21

Hetero atoms7

Rings / aromatic3 / 2

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

31 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	0.072	uM	-	—	-	-	H929	CN116457344A	PGDB_A007061	PGDB_C008731	PGDB_AS000797	View
IC50	-	=	1653.2	nM	-	—	-	-	Daudi	WO2023151635A1	PGDB_A007197	PGDB_C008731	PGDB_AS000279	View
IC50	-	=	0.034	uM	-	—	-	-	-	JP6306592B2	PGDB_A008691	PGDB_C008731	PGDB_AS000268	View
IC50	-	=	1.07	uM	-	—	CRBN	CRBN	-	WO2023151635A1	PGDB_A008767	PGDB_C008731	PGDB_AS000788	View
Ki	-	=	1-5	uM	-	—	CRBN	CRBN	-	WO2022146151A1	PGDB_A011992	PGDB_C008731	PGDB_AS002364	View
IC50	-	=	0.95	uM	-	—	-	-	-	JP6306592B2	PGDB_A016472	PGDB_C008731	PGDB_AS001022	View
Ki	-	=	1-10	uM	-	—	CRBN	CRBN	-	AU2020392427A1	PGDB_A018383	PGDB_C008731	PGDB_AS000153	View
Relative activity	control	=	480	%	-	-	-	-	-	JP6306592B2	PGDB_A022040	PGDB_C008731	PGDB_AS002248	View
IC50	-	=	1326	nM	-	—	-	-	Ramos	WO2023151635A1	PGDB_A023324	PGDB_C008731	PGDB_AS002135	View
IC50	-	>	10000	nM	-	—	-	-	Kasumi-1	WO2023151635A1	PGDB_A030941	PGDB_C008731	PGDB_AS001646	View
IC50	-	=	0.062	uM	-	—	-	-	-	JP6306592B2	PGDB_A032017	PGDB_C008731	PGDB_AS000318	View
IC50	-	=	0.15-20	uM	-	—	-	-	Mino	WO2020114482A1	PGDB_A035658	PGDB_C008731	PGDB_AS000154	View
IC50	-	>	10	uM	-	—	-	-	-	JP6306592B2	PGDB_A040215	PGDB_C008731	PGDB_AS001058	View
IC50	-	=	464.4	nM	-	—	-	-	MM.1R	WO2023151635A1	PGDB_A041227	PGDB_C008731	PGDB_AS001111	View
IC50	-	>	20	uM	-	—	-	-	MV-4-11	WO2020114482A1	PGDB_A041815	PGDB_C008731	PGDB_AS001277	View
Relative activity	control	=	131	%	-	-	-	-	-	JP6306592B2	PGDB_A046228	PGDB_C008731	PGDB_AS001193	View
% Inhibition	-	>	20	%	-	7 d	-	-	MV-4-11	WO2020064002A1	PGDB_A050571	PGDB_C008731	PGDB_AS001761	View
IC50	-	=	46.9	nM	-	—	-	-	MM.1S	WO2023151635A1	PGDB_A051193	PGDB_C008731	PGDB_AS002383	View
IC50	-	=	890.3	nM	-	—	-	-	TMD8	WO2023151635A1	PGDB_A051539	PGDB_C008731	PGDB_AS000648	View
IC50	-	=	0.06	uM	-	—	-	-	-	JP6306592B2	PGDB_A053960	PGDB_C008731	PGDB_AS000129	View

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