PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN118984820A

AssigneeSanofi Aventis France

TitleNovel substituted fluorinated N-propyl-pyrrolidine compounds, methods for their preparation and therapeutic uses

Family ID81579602

Family members5

Filing year2023

Publication date2024-11-19

JurisdictionCN

Compounds41

Activity records90

Assays4

Activity compounds and values

Activity records

90 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	0.8	nM	-	—	ESR1	-	MCF-7	PGDB_A008714	PGDB_C006912	PGDB_AS000996	View
IC50	-	=	1.3	nM	-	—	ESR1	-	MCF-7	PGDB_A012432	PGDB_C006920	PGDB_AS000996	View
IC50	-	=	0.8	nM	-	—	ESR1	-	MCF-7	PGDB_A012912	PGDB_C006901	PGDB_AS000996	View
IC50	-	=	0.4	nM	-	—	ER	-	LNCaP	PGDB_A013406	PGDB_C006923	PGDB_AS001923	View
IC50	-	=	78.8	nM	-	—	ESR1	-	MCF-7	PGDB_A013992	PGDB_C006920	PGDB_AS000996	View
IC50	-	=	0.8	nM	-	—	ESR1	-	MCF-7	PGDB_A014181	PGDB_C006914	PGDB_AS000996	View
IC50	-	=	5.4	nM	-	—	ESR1	-	MCF-7	PGDB_A014290	PGDB_C006889	PGDB_AS000996	View
IC50	-	=	0.9	nM	-	—	ESR1	-	MCF-7	PGDB_A015732	PGDB_C006913	PGDB_AS000996	View
IC50	-	=	1.5	nM	-	—	ESR1	-	MCF-7	PGDB_A016145	PGDB_C006886	PGDB_AS000996	View
% Degradation	-	=	90	%	0.3 uM	4 h	ESR1	-	MCF-7	PGDB_A016717	PGDB_C006894	PGDB_AS001441	View
IC50	-	=	1.2	nM	-	—	ESR1	-	MCF-7	PGDB_A017455	PGDB_C006922	PGDB_AS000996	View
IC50	-	=	1.6	nM	-	—	ESR1	-	MCF-7	PGDB_A017584	PGDB_C006919	PGDB_AS000996	View
% Degradation	-	=	80	%	0.3 uM	4 h	ESR1	-	MCF-7	PGDB_A019029	PGDB_C006887	PGDB_AS001441	View
% Degradation	-	=	69	%	0.3 uM	4 h	ESR1	-	MCF-7	PGDB_A019710	PGDB_C006903	PGDB_AS001441	View
IC50	-	=	2	nM	-	—	ESR1	-	MCF-7	PGDB_A019931	PGDB_C006918	PGDB_AS000996	View
IC50	-	=	1.4	nM	-	—	ESR1	-	MCF-7	PGDB_A021332	PGDB_C006891	PGDB_AS000996	View
IC50	-	=	0.9	nM	-	—	ESR1	-	MCF-7	PGDB_A021898	PGDB_C006906	PGDB_AS000996	View
% Degradation	-	=	73	%	0.3 uM	4 h	ESR1	-	MCF-7	PGDB_A022724	PGDB_C006906	PGDB_AS001441	View
IC50	-	=	0.3	nM	-	—	ESR1	-	MCF-7	PGDB_A023258	PGDB_C006892	PGDB_AS000996	View
% Degradation	-	=	84	%	0.3 uM	4 h	ESR1	-	MCF-7	PGDB_A024639	PGDB_C006905	PGDB_AS001441	View

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