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Patent
CN121368591A
3 compounds62 activity records22 assays
Patent summary
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Dmax | - | = | 69 | % | Concentration context: titrated doses | 24 h | IKZF1 | - | - | PGDB_A007142 | PGDB_C007371 | PGDB_AS002355 | View |
 | Dmax | - | = | 74 | % | Concentration context: titrated doses | 24 h | IKZF1 | - | - | PGDB_A008524 | PGDB_C007372 | PGDB_AS002355 | View |
| Dmax | - | = | 27 | % | - | 72 h | IKZF2 | - | Jurkat | PGDB_A012062 | PGDB_C007372 | PGDB_AS002303 | View |
| DC50 | - | = | 1520 | nM | - | — | IKZF1 | - | Jurkat | PGDB_A012396 | PGDB_C007372 | PGDB_AS000891 | View |
| Dmax | - | = | 68-71 | % | Concentration context: titrated doses | 13 d | IKZF4 | - | - | PGDB_A013179 | PGDB_C007371 | PGDB_AS000067 | View |
| Dmax | - | = | 86-92 | % | Concentration context: titrated doses | 13 d | IKZF2 | - | - | PGDB_A015022 | PGDB_C007371 | PGDB_AS002527 | View |
| % Degradation | - | = | 69 | % | Concentration context: titrated doses of compound | 24 h | IKZF1 | - | - | PGDB_A015826 | PGDB_C007371 | PGDB_AS001917 | View |
| DC50 | - | = | 0.68 | nM | - | — | IKZF2 | - | - | PGDB_A017156 | PGDB_C007371 | PGDB_AS001784 | View |
 | Dmax | - | = | 47 | % | - | 20 h | IKZF1 | - | - | PGDB_A017302 | PGDB_C007373 | PGDB_AS002077 | View |
| DC50 | - | > | 1000 | nM | - | — | IKZF1 | - | - | PGDB_A018392 | PGDB_C007373 | PGDB_AS000417 | View |
| DC50 | - | > | 10000 | nM | - | — | IKZF1 | - | - | PGDB_A019630 | PGDB_C007373 | PGDB_AS000394 | View |
| Dmax | - | = | 1 | % | Concentration context: titrated doses | 13 d | IKZF2 | - | - | PGDB_A020560 | PGDB_C007372 | PGDB_AS002527 | View |
| % Degradation | - | = | 74 | % | Concentration context: titrated doses of compound | 24 h | IKZF1 | - | - | PGDB_A021804 | PGDB_C007372 | PGDB_AS001917 | View |
| % Degradation | - | = | 69-74 | % | Concentration context: titrated doses | 24 h | IKZF3 | - | - | PGDB_A022995 | PGDB_C007371 | PGDB_AS000860 | View |
| Dmax | - | = | 93 | % | - | 72 h | IKZF2 | - | Jurkat | PGDB_A025095 | PGDB_C007371 | PGDB_AS002303 | View |
| DC50 | - | = | 1.1-1.4 | nM | - | — | IKZF2 | - | - | PGDB_A025826 | PGDB_C007371 | PGDB_AS002365 | View |
| DC50 | - | > | 1000 | nM | - | — | IKZF2 | - | - | PGDB_A026464 | PGDB_C007373 | PGDB_AS002365 | View |
| DC50 | - | = | 21 | nM | - | — | IKZF3 | - | - | PGDB_A031987 | PGDB_C007372 | PGDB_AS000126 | View |
| DC50 | - | > | 10000 | nM | - | — | IKZF3 | - | Jurkat | PGDB_A032279 | PGDB_C007373 | PGDB_AS001531 | View |
| DC50 | - | = | 17.9 | nM | - | — | IKZF2 | - | Jurkat | PGDB_A032589 | PGDB_C007371 | PGDB_AS000667 | View |