PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(n2cc(-c3ccc(Br)cc3F)oc2=O)C(=O)N1

Compound summary

Compound IDPGDB_C007373

FormulaC14H10BrFN2O4

Molecular weight369.146

InChIKeyVACYFJWFXFNBTI-UHFFFAOYSA-N

Physicochemical properties

Exact mass367.9808

RDKit cLogP1.99

TPSA81.3

HBD / HBA1 / 5

Rotatable bonds2

Heavy atoms22

Hetero atoms8

Rings / aromatic3 / 2

Fraction Csp30.21

Formal charge0

Fragments1

Activity compounds and values

Activity records

56 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	11	%	-	-	IKZF4	-	-	US20250129061A1	PGDB_A012502	PGDB_C007373	PGDB_AS001833	View
Dmax	-	=	15	%	-	72 h	IKZF3	-	Jurkat	US20250129061A1	PGDB_A012987	PGDB_C007373	PGDB_AS001493	View
DC50	-	>	1000	nM	-	—	IKZF4	-	-	WO2025049840	PGDB_A016796	PGDB_C007373	PGDB_AS001336	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	US20250129061A1	PGDB_A016906	PGDB_C007373	PGDB_AS000744	View
Dmax	-	=	47	%	-	20 h	IKZF1	-	-	CN121368591A	PGDB_A017302	PGDB_C007373	PGDB_AS002077	View
DC50	-	>	1000	nM	-	—	-	-	primary human PBMC	WO2025049840	PGDB_A017529	PGDB_C007373	PGDB_AS001952	View
Dmax	-	=	0	%	-	-	IKZF3	-	-	US20250129061A1	PGDB_A017873	PGDB_C007373	PGDB_AS001745	View
DC50	-	>	1000	nM	-	—	IKZF1	-	-	CN121368591A	PGDB_A018392	PGDB_C007373	PGDB_AS000417	View
DC50	-	>	1000	nM	-	—	IKZF4	-	-	US20250129061A1	PGDB_A019349	PGDB_C007373	PGDB_AS002356	View
DC50	-	>	10000	nM	-	—	IKZF1	-	-	CN121368591A	PGDB_A019630	PGDB_C007373	PGDB_AS000394	View
Dmax	-	=	11	%	-	24 h	IKZF2	-	Jurkat	WO2025049840	PGDB_A021770	PGDB_C007373	PGDB_AS001341	View
Dmax	-	=	11	%	-	-	IKZF2	-	Jurkat	WO2025049840	PGDB_A021941	PGDB_C007373	PGDB_AS000207	View
Dmax	-	=	0	%	Concentration context: titrated doses	24 h	IKZF3	-	-	US20250129061A1	PGDB_A025925	PGDB_C007373	PGDB_AS001021	View
DC50	-	>	1000	nM	-	—	IKZF2	-	-	CN121368591A	PGDB_A026464	PGDB_C007373	PGDB_AS002365	View
Dmax	-	=	11	%	-	-	IKZF4	-	-	WO2025049840	PGDB_A026872	PGDB_C007373	PGDB_AS001208	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	CN121368591A	PGDB_A032279	PGDB_C007373	PGDB_AS001531	View
DC50	-	>	10000	nM	-	—	IKZF1	-	Jurkat	WO2025049840	PGDB_A036225	PGDB_C007373	PGDB_AS002315	View
DC50	-	>	10000	nM	-	—	IKZF1	-	Jurkat	CN121368591A	PGDB_A036656	PGDB_C007373	PGDB_AS000891	View
Dmax	-	=	0	%	-	-	IKZF3	-	-	WO2025049840	PGDB_A036869	PGDB_C007373	PGDB_AS001160	View
DC50	-	>	1000	nM	-	—	IKZF1	-	-	US20250129061A1	PGDB_A037315	PGDB_C007373	PGDB_AS000255	View

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