PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025224262A1

AssigneeMonte Rosa Therapeutics

TitleCombination therapies comprising a cdk2 degrader and a cdk4/6 inhibitor

Family ID95560669

Family members1

Filing year2025

Publication date2025-10-30

JurisdictionWO

Compounds131

Activity records168

Assays5

Activity compounds and values

Activity records

168 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
DC50	-	=	9.6	nM	-	—	CDK2	-	HEK293	PGDB_A007333	PGDB_C011769	PGDB_AS001903	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A008432	PGDB_C027487	PGDB_AS001844	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A009003	PGDB_C027491	PGDB_AS001844	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A009443	PGDB_C027570	PGDB_AS001844	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A010461	PGDB_C027480	PGDB_AS001844	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A010661	PGDB_C027558	PGDB_AS001844	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A011400	PGDB_C027554	PGDB_AS001844	View
Dmax	-	>	80	%	30 uM	24 h	CDK2	-	HEK293	PGDB_A011720	PGDB_C027528	PGDB_AS001415	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A012036	PGDB_C027488	PGDB_AS001844	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A012436	PGDB_C027495	PGDB_AS001844	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A012770	PGDB_C027517	PGDB_AS001844	View
Dmax	-	>	80	%	30 uM	24 h	CDK2	-	HEK293	PGDB_A012797	PGDB_C027542	PGDB_AS001415	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A012975	PGDB_C027576	PGDB_AS001844	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A013009	PGDB_C027528	PGDB_AS001844	View
Dmax	-	>	80	%	30 uM	24 h	CDK2	-	HEK293	PGDB_A013708	PGDB_C027508	PGDB_AS001415	View
Dmax	-	>	80	%	30 uM	24 h	CDK2	-	HEK293	PGDB_A013788	PGDB_C027498	PGDB_AS001415	View
Dmax	-	>	80	%	30 uM	24 h	CDK2	-	HEK293	PGDB_A014212	PGDB_C011831	PGDB_AS001415	View
DC50	-	=	26.4	nM	-	—	CDK2	-	HEK293	PGDB_A014531	PGDB_C011768	PGDB_AS001903	View
Dmax	-	>	80	%	30 uM	24 h	CDK2	-	HEK293	PGDB_A014713	PGDB_C027501	PGDB_AS001415	View
Ki	-	<=	0.1	uM	-	—	CRBN	CRBN	-	PGDB_A015029	PGDB_C027468	PGDB_AS001844	View

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