PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026007898A1

AssigneeShanghai Haiyan Pharmaceutical Technology, Yangtze River Pharmaceutical Group

TitleIsoindoline compound containing phenoxyalkylamine structure, pharmaceutical composition comprising same, and use thereof

Family ID98317638

Family members1

Filing year2025

Publication date2026-01-08

JurisdictionWO

Compounds37

Activity records75

Assays6

Activity compounds and values

Activity records

75 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	8	nM	-	—	-	-	MDA-MB-453	PGDB_A009179	PGDB_C003368	PGDB_AS002028	View
IC50	-	=	1.2	nM	-	—	-	-	MDA-MB-453	PGDB_A009278	PGDB_C003376	PGDB_AS002028	View
IC50	-	=	1834	nM	-	—	-	-	MDA-MB-453	PGDB_A010585	PGDB_C003375	PGDB_AS002028	View
DC50	-	=	1648	nM	-	—	IKZF1	-	-	PGDB_A010967	PGDB_C003382	PGDB_AS002166	View
DC50	-	=	77	nM	-	—	GSPT1	-	-	PGDB_A010972	PGDB_C003396	PGDB_AS002374	View
DC50	-	>	10000	nM	-	—	IKZF3	-	-	PGDB_A011249	PGDB_C003397	PGDB_AS002393	View
IC50	-	=	2	nM	-	—	-	-	MDA-MB-453	PGDB_A011614	PGDB_C003385	PGDB_AS002028	View
IC50	-	=	267	nM	-	—	-	-	MDA-MB-453	PGDB_A013277	PGDB_C003388	PGDB_AS002028	View
Selectivity index	IKZF1	>	270	fold	-	—	-	-	-	PGDB_A014241	PGDB_C003400	PGDB_AS001314	View
IC50	-	=	51	nM	-	—	-	-	MDA-MB-453	PGDB_A014408	PGDB_C003372	PGDB_AS002028	View
IC50	-	=	2	nM	-	—	-	-	MDA-MB-453	PGDB_A014982	PGDB_C003367	PGDB_AS002028	View
Selectivity index	IKZF1	=	16	fold	-	—	-	-	-	PGDB_A017836	PGDB_C003382	PGDB_AS001314	View
IC50	-	=	39	nM	-	—	-	-	MDA-MB-453	PGDB_A018125	PGDB_C003391	PGDB_AS002028	View
DC50	-	>	10000	nM	-	—	IKZF1	-	-	PGDB_A018934	PGDB_C003379	PGDB_AS002166	View
IC50	-	=	151	nM	-	—	-	-	MDA-MB-453	PGDB_A021331	PGDB_C003380	PGDB_AS002028	View
Selectivity index	IKZF1	>	130	fold	-	—	-	-	-	PGDB_A022505	PGDB_C003396	PGDB_AS001314	View
IC50	-	=	109	nM	-	—	-	-	MDA-MB-453	PGDB_A023331	PGDB_C003390	PGDB_AS002028	View
IC50	-	=	45	nM	-	—	-	-	MDA-MB-453	PGDB_A023492	PGDB_C003374	PGDB_AS002028	View
IC50	-	=	3	nM	-	—	-	-	MDA-MB-453	PGDB_A023742	PGDB_C003383	PGDB_AS002028	View
Selectivity index	IKZF1	>	2012	fold	-	—	-	-	-	PGDB_A024503	PGDB_C003379	PGDB_AS001314	View

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