PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026099466A1

AssigneeMonte Rosa Therapeutics

TitleGLUE DEGRADERS OF NEK7 AND THERAPEUTIC USES THEREOF

Family IDunresolved_family_WO2026099466A1

Family members1

Filing year2025

Publication date2026-05-15

JurisdictionWO

Compounds130

Activity records402

Assays5

Activity compounds and values

Activity records

402 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	93	%	Concentration series: 1 uM, 0.05 nM	-	NEK7	-	CAL-51	PGDB_A000004	PGDB_C031206	PGDB_AS000358	View
EC50	-	=	1.2	uM	-	—	CRBN	CRBN	-	PGDB_A000010	PGDB_C031256	PGDB_AS002171	View
EC50	-	=	2.7	uM	-	—	CRBN	CRBN	-	PGDB_A000019	PGDB_C031289	PGDB_AS002171	View
Dmax	-	=	49	%	Concentration series: 1 uM, 0.05 nM	-	NEK7	-	CAL-51	PGDB_A000077	PGDB_C031279	PGDB_AS000358	View
EC50	-	=	1.7	uM	-	—	CRBN	CRBN	-	PGDB_A000151	PGDB_C031302	PGDB_AS002171	View
IC50	-	=	0.108	uM	-	—	CASP1	-	monocyte-derivedmacrophages	PGDB_A000180	PGDB_C031217	PGDB_AS002042	View
EC50	-	=	1.8	uM	-	—	CRBN	CRBN	-	PGDB_A000219	PGDB_C031326	PGDB_AS002171	View
DC50	-	=	17	nM	-	—	NEK7	-	CAL-51	PGDB_A000222	PGDB_C031257	PGDB_AS000897	View
EC50	-	=	3.3	uM	-	—	CRBN	CRBN	-	PGDB_A000235	PGDB_C031225	PGDB_AS002171	View
EC50	-	=	1.2	uM	-	—	CRBN	CRBN	-	PGDB_A000242	PGDB_C031292	PGDB_AS002171	View
Dmax	-	=	40	%	Concentration series: 1 uM, 0.05 nM	-	NEK7	-	CAL-51	PGDB_A000322	PGDB_C031324	PGDB_AS000358	View
Dmax	-	=	59	%	Concentration series: 1 uM, 0.05 nM	-	NEK7	-	CAL-51	PGDB_A000333	PGDB_C031265	PGDB_AS000358	View
EC50	-	=	1.9	uM	-	—	CRBN	CRBN	-	PGDB_A000352	PGDB_C031299	PGDB_AS002171	View
DC50	-	=	159	nM	-	—	NEK7	-	CAL-51	PGDB_A000371	PGDB_C031208	PGDB_AS000897	View
Dmax	-	=	93	%	Concentration series: 1 uM, 0.05 nM	-	NEK7	-	CAL-51	PGDB_A000389	PGDB_C031236	PGDB_AS000358	View
DC50	-	=	79	nM	-	—	NEK7	-	CAL-51	PGDB_A000405	PGDB_C031239	PGDB_AS000897	View
EC50	-	=	1.4	uM	-	—	CRBN	CRBN	-	PGDB_A000453	PGDB_C031228	PGDB_AS002171	View
DC50	-	=	8	nM	-	—	NEK7	-	CAL-51	PGDB_A000457	PGDB_C031273	PGDB_AS000897	View
Dmax	-	=	62	%	Concentration series: 1 uM, 0.05 nM	-	NEK7	-	CAL-51	PGDB_A000652	PGDB_C031306	PGDB_AS000358	View
EC50	-	=	2.4	uM	-	—	CRBN	CRBN	-	PGDB_A000688	PGDB_C031314	PGDB_AS002171	View

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