Assay

PGDB_AS001868

System: cell_basedTarget: CSNK1A1Cell line: HT-1080
Assay context summary

Assay context

83 activity records
Assay family% Degradation
Systemcell_based
ReadoutDC50
TargetCSNK1A1
E3CRBN
Cell lineHT-1080
OrganismHomo sapiens
Technologyluminescence
Detection targetprotein_degradation
Activity compounds and values

Activity records

83 records
StructureMetricControlRelationValueUnitConcentrationTimeTargetE3Cell linePatentRecord IDCompoundAssayDetails
2D structure for PGDB_C001790
DC50-=0.243uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A007371PGDB_C001790PGDB_AS001868View
2D structure for PGDB_C001858
DC50-=0.219uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A011329PGDB_C001858PGDB_AS001868View
2D structure for PGDB_C001856
DC50-=0.233uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A011411PGDB_C001856PGDB_AS001868View
2D structure for PGDB_C001839
DC50-=0.652uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A011585PGDB_C001839PGDB_AS001868View
2D structure for PGDB_C001860
DC50-=0.0939uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A011747PGDB_C001860PGDB_AS001868View
2D structure for PGDB_C001857
DC50-=3.88uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A013158PGDB_C001857PGDB_AS001868View
2D structure for PGDB_C001803
DC50-=0.0659uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A013279PGDB_C001803PGDB_AS001868View
2D structure for PGDB_C001794
DC50-=0.706uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A014533PGDB_C001794PGDB_AS001868View
2D structure for PGDB_C001854
DC50-=0.132uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A014948PGDB_C001854PGDB_AS001868View
2D structure for PGDB_C001844
DC50-<0.0471uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A015598PGDB_C001844PGDB_AS001868View
2D structure for PGDB_C001788
DC50-=0.18uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A017457PGDB_C001788PGDB_AS001868View
2D structure for PGDB_C001823
DC50-=1.58uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A017732PGDB_C001823PGDB_AS001868View
2D structure for PGDB_C001831
DC50-=1.3uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A019372PGDB_C001831PGDB_AS001868View
2D structure for PGDB_C001808
DC50-=1.15uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A019522PGDB_C001808PGDB_AS001868View
2D structure for PGDB_C001855
DC50-=0.0735uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A019960PGDB_C001855PGDB_AS001868View
2D structure for PGDB_C001846
DC50-=0.162uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A020162PGDB_C001846PGDB_AS001868View
2D structure for PGDB_C001859
DC50-=0.0741uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A021074PGDB_C001859PGDB_AS001868View
2D structure for PGDB_C001815
DC50-=0.142uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A021364PGDB_C001815PGDB_AS001868View
2D structure for PGDB_C001853
DC50-=0.455uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A021448PGDB_C001853PGDB_AS001868View
2D structure for PGDB_C001832
DC50-=0.446uM-—CSNK1A1CRBNHT-1080WO2022257897A1PGDB_A022164PGDB_C001832PGDB_AS001868View
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