PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2022257897A1

AssigneeHangzhou Glubio Pharmaceutical

TitleIsoindolinone compounds, and uses thereof

Family ID84424760

Family members11

Filing year2022

Publication date2022-12-15

JurisdictionWO

Compounds82

Activity records286

Assays5

Activity compounds and values

Activity records

286 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	0.06	uM	-	—	CSNK1A1	-	MV-4-11	PGDB_A007363	PGDB_C001841	PGDB_AS000623	View
DC50	-	=	0.243	uM	-	—	CSNK1A1	CRBN	HT-1080	PGDB_A007371	PGDB_C001790	PGDB_AS001868	View
Dmax	-	=	19.1	%	10 uM	20 h	GSPT1	CRBN	HT-1080	PGDB_A007839	PGDB_C001853	PGDB_AS000618	View
Dmax	-	=	68.1	%	10 uM	20 h	CSNK1A1	CRBN	HT-1080	PGDB_A007894	PGDB_C001801	PGDB_AS000920	View
Dmax	-	=	60.8	%	10 uM	20 h	CSNK1A1	CRBN	HT-1080	PGDB_A008412	PGDB_C001794	PGDB_AS000920	View
Dmax	-	=	66	%	10 uM	20 h	CSNK1A1	CRBN	HT-1080	PGDB_A008471	PGDB_C001842	PGDB_AS000920	View
Dmax	-	=	49.3	%	10 uM	20 h	GSPT1	CRBN	HT-1080	PGDB_A008752	PGDB_C001801	PGDB_AS000618	View
Dmax	-	=	64.1	%	10 uM	20 h	CSNK1A1	CRBN	HT-1080	PGDB_A009193	PGDB_C001835	PGDB_AS000920	View
Dmax	-	=	47.9	%	10 uM	20 h	GSPT1	CRBN	HT-1080	PGDB_A009419	PGDB_C001816	PGDB_AS000618	View
Dmax	-	=	42	%	10 uM	20 h	GSPT1	CRBN	HT-1080	PGDB_A010132	PGDB_C001804	PGDB_AS000618	View
Dmax	-	=	31.7	%	10 uM	20 h	GSPT1	CRBN	HT-1080	PGDB_A011083	PGDB_C001849	PGDB_AS000618	View
DC50	-	=	0.219	uM	-	—	CSNK1A1	CRBN	HT-1080	PGDB_A011329	PGDB_C001858	PGDB_AS001868	View
DC50	-	=	0.233	uM	-	—	CSNK1A1	CRBN	HT-1080	PGDB_A011411	PGDB_C001856	PGDB_AS001868	View
Dmax	-	=	30.6	%	10 uM	20 h	GSPT1	CRBN	HT-1080	PGDB_A011475	PGDB_C001806	PGDB_AS000618	View
Dmax	-	=	42.7	%	10 uM	20 h	GSPT1	CRBN	HT-1080	PGDB_A011560	PGDB_C001814	PGDB_AS000618	View
DC50	-	=	0.652	uM	-	—	CSNK1A1	CRBN	HT-1080	PGDB_A011585	PGDB_C001839	PGDB_AS001868	View
DC50	-	=	0.0939	uM	-	—	CSNK1A1	CRBN	HT-1080	PGDB_A011747	PGDB_C001860	PGDB_AS001868	View
Dmax	-	=	49.5	%	10 uM	20 h	CSNK1A1	CRBN	HT-1080	PGDB_A011960	PGDB_C001810	PGDB_AS000920	View
Dmax	-	=	70.8	%	10 uM	20 h	GSPT1	CRBN	HT-1080	PGDB_A011967	PGDB_C001826	PGDB_AS000618	View
Dmax	-	=	14.9	%	10 uM	20 h	GSPT1	CRBN	HT-1080	PGDB_A012267	PGDB_C001863	PGDB_AS000618	View

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