PatGlueDB | Molecular Glue Patent Bioactivity Database

Assay context summary

Assay context

66 activity records

Assay family% Degradation

Systemcell_based

Readout% Degradation

TargetGSPT1

E3Not specified

Cell lineJeKo-1

TechnologyWestern_blot

Detection targetprotein_degradation

Activity compounds and values

Activity records

66 records

Metric	Control	Relation	Value	Unit	Concentration	Time	Target	E3	Cell line	Patent	Record ID	Compound	Assay	Details
% Degradation	-	=	38.1	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A008346	PGDB_C005341	PGDB_AS002119	View
% Degradation	-	=	11.6	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A009031	PGDB_C005356	PGDB_AS002119	View
% Degradation	-	=	33	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A009788	PGDB_C005315	PGDB_AS002119	View
% Degradation	-	=	100	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A014777	PGDB_C005328	PGDB_AS002119	View
% Degradation	-	=	96	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A014797	PGDB_C005322	PGDB_AS002119	View
% Degradation	-	=	93	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A015297	PGDB_C005323	PGDB_AS002119	View
% Degradation	-	=	77.7	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A015736	PGDB_C005355	PGDB_AS002119	View
% Degradation	-	=	96.2	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A016297	PGDB_C005351	PGDB_AS002119	View
% Degradation	-	=	51	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A016861	PGDB_C005345	PGDB_AS002119	View
% Degradation	-	=	99	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A017320	PGDB_C005358	PGDB_AS002119	View
% Degradation	-	=	65.2	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A017741	PGDB_C005347	PGDB_AS002119	View
% Degradation	-	=	70	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A019167	PGDB_C005332	PGDB_AS002119	View
% Degradation	-	=	21	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A019487	PGDB_C005321	PGDB_AS002119	View
% Degradation	-	=	32	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A020538	PGDB_C005312	PGDB_AS002119	View
% Degradation	-	=	96.9	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A022568	PGDB_C005316	PGDB_AS002119	View
% Degradation	-	=	82	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A022723	PGDB_C005306	PGDB_AS002119	View
% Degradation	-	=	97.8	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A023506	PGDB_C005309	PGDB_AS002119	View
% Degradation	-	=	93	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A024219	PGDB_C005298	PGDB_AS002119	View
% Degradation	-	=	79	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A024826	PGDB_C005327	PGDB_AS002119	View
% Degradation	-	=	17	%	100 nM	24 h	GSPT1	-	JeKo-1	WO2023078410A1	PGDB_A025142	PGDB_C005313	PGDB_AS002119	View

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