PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2023078410A1

AssigneeFudan University, Shanghai Meizer Pharmaceuticals

TitleCompounds with GSPT1 degradation activity and applications thereof

Family ID86206824

Family members4

Filing year2022

Publication date2024-06-14

JurisdictionWO

Compounds66

Activity records185

Assays5

Activity compounds and values

Activity records

185 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	38.1	%	100 nM	24 h	GSPT1	-	JeKo-1	PGDB_A008346	PGDB_C005341	PGDB_AS002119	View
% Degradation	-	=	56	%	10 uM	24 h	GSPT1	-	JeKo-1	PGDB_A008510	PGDB_C005320	PGDB_AS000305	View
IC50	-	=	11.6	nM	-	—	GSPT1	-	HL-60	PGDB_A008888	PGDB_C005331	PGDB_AS002047	View
% Degradation	-	=	11.6	%	100 nM	24 h	GSPT1	-	JeKo-1	PGDB_A009031	PGDB_C005356	PGDB_AS002119	View
% Degradation	-	=	95	%	10 uM	24 h	GSPT1	-	JeKo-1	PGDB_A009617	PGDB_C005331	PGDB_AS000305	View
% Degradation	-	=	97	%	10 uM	24 h	GSPT1	-	JeKo-1	PGDB_A009651	PGDB_C005311	PGDB_AS000305	View
% Degradation	-	=	33	%	100 nM	24 h	GSPT1	-	JeKo-1	PGDB_A009788	PGDB_C005315	PGDB_AS002119	View
IC50	-	=	14.3	nM	-	—	GSPT1	-	HL-60	PGDB_A010274	PGDB_C005327	PGDB_AS002047	View
% Degradation	-	=	95.6	%	10 uM	24 h	GSPT1	-	JeKo-1	PGDB_A012097	PGDB_C005329	PGDB_AS000305	View
IC50	-	=	6.2	nM	-	—	GSPT1	-	HNT-34	PGDB_A014569	PGDB_C005308	PGDB_AS000001	View
IC50	-	=	26.9	nM	-	—	GSPT1	-	HNT-34	PGDB_A014587	PGDB_C005300	PGDB_AS000001	View
% Degradation	-	=	100	%	100 nM	24 h	GSPT1	-	JeKo-1	PGDB_A014777	PGDB_C005328	PGDB_AS002119	View
% Degradation	-	=	96	%	100 nM	24 h	GSPT1	-	JeKo-1	PGDB_A014797	PGDB_C005322	PGDB_AS002119	View
% Degradation	-	=	93	%	100 nM	24 h	GSPT1	-	JeKo-1	PGDB_A015297	PGDB_C005323	PGDB_AS002119	View
% Degradation	-	=	97	%	10 uM	24 h	GSPT1	-	JeKo-1	PGDB_A015727	PGDB_C005302	PGDB_AS000305	View
% Degradation	-	=	77.7	%	100 nM	24 h	GSPT1	-	JeKo-1	PGDB_A015736	PGDB_C005355	PGDB_AS002119	View
% Degradation	-	=	96.2	%	100 nM	24 h	GSPT1	-	JeKo-1	PGDB_A016297	PGDB_C005351	PGDB_AS002119	View
% Degradation	-	=	80	%	10 uM	24 h	GSPT1	-	JeKo-1	PGDB_A016595	PGDB_C005340	PGDB_AS000305	View
% Degradation	-	=	77	%	10 uM	24 h	GSPT1	-	JeKo-1	PGDB_A016833	PGDB_C005313	PGDB_AS000305	View
% Degradation	-	=	51	%	100 nM	24 h	GSPT1	-	JeKo-1	PGDB_A016861	PGDB_C005345	PGDB_AS002119	View

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