PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(N5CCN(c6cccc(Cl)c6Cl)CC5)C(F)(F)C4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000740

FormulaC29H31Cl2F2N5O3

Molecular weight606.501

InChIKeyWGMNIFVINNYNBI-UHFFFAOYSA-N

Physicochemical properties

Exact mass605.1772

RDKit cLogP3.79

TPSA76.2

HBD / HBA1 / 6

Rotatable bonds5

Heavy atoms41

Hetero atoms12

Rings / aromatic6 / 2

Fraction Csp30.48

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	<	5	%	10 nM	-	-	-	SW620	CN120548310A	PGDB_A009785	PGDB_C000740	PGDB_AS001642	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A010241	PGDB_C000740	PGDB_AS001466	View
IC50	-	<=	0.1	uM	-	—	CRBN	CRBN	-	CN120548310A	PGDB_A012527	PGDB_C000740	PGDB_AS000323	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MOLT-4	CN120548310A	PGDB_A023303	PGDB_C000740	PGDB_AS000553	View
% Inhibition	-	=	40-50	%	500 nM	-	-	-	JeKo-1	CN120548310A	PGDB_A024475	PGDB_C000740	PGDB_AS002242	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	MM.1S	CN120548310A	PGDB_A032380	PGDB_C000740	PGDB_AS001316	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A035672	PGDB_C000740	PGDB_AS000102	View
% Inhibition	-	=	20-30	%	10 nM	-	-	-	MOLT-4	CN120548310A	PGDB_A036702	PGDB_C000740	PGDB_AS001814	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A040695	PGDB_C000740	PGDB_AS001655	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A062133	PGDB_C000740	PGDB_AS002025	View
% Inhibition	-	=	40-50	%	500 nM	-	-	-	SW620	CN120548310A	PGDB_A063187	PGDB_C000740	PGDB_AS001503	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A064907	PGDB_C000740	PGDB_AS000946	View
% Inhibition	-	=	50-60	%	10 nM	96 h	-	-	MM.1S	CN120548310A	PGDB_A070080	PGDB_C000740	PGDB_AS000332	View
% Inhibition	-	=	5-10	%	10 nM	-	-	-	JeKo-1	CN120548310A	PGDB_A071011	PGDB_C000740	PGDB_AS001869	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A077167	PGDB_C000740	PGDB_AS001449	View

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