PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(N5CCN(C(c6ccccc6)c6ccccc6)CC5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000757

FormulaC36H41N5O3

Molecular weight591.756

InChIKeyFWDSNWHESJRBPF-UHFFFAOYSA-N

Physicochemical properties

Exact mass591.3209

RDKit cLogP3.82

TPSA76.2

HBD / HBA1 / 6

Rotatable bonds7

Heavy atoms44

Hetero atoms8

Rings / aromatic7 / 3

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A022103	PGDB_C000757	PGDB_AS000946	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A022330	PGDB_C000757	PGDB_AS001449	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A029729	PGDB_C000757	PGDB_AS002025	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A036226	PGDB_C000757	PGDB_AS001466	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	CN120548310A	PGDB_A048349	PGDB_C000757	PGDB_AS000323	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A049931	PGDB_C000757	PGDB_AS000102	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A055419	PGDB_C000757	PGDB_AS001655	View

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