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Compound
PGDB_C005652
6 activity records1 related patents
2D structure
CCN(C)S(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn([C@H]4COC5(CCN(C(=O)CC6(O)CCN(c7cc8c(cc7F)c(N7CCC(=O)NC7=O)nn8C)CC6)CC5)C4)c(=O)c3c2)c1C#NCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 7.8 | nM | - | — | EPHB2 | - | A375-NRASQ61K | AU2022290851A1 | PGDB_A012474 | PGDB_C005652 | PGDB_AS000786 | View |
| IC50 | - | = | 3.2 | nM | - | — | EPHB2 | - | A375 | AU2022290851A1 | PGDB_A013241 | PGDB_C005652 | PGDB_AS002217 | View |
| Emax | - | = | 27.48 | % | 10 uM | 24 h | BRAF | - | A375.10 | AU2022290851A1 | PGDB_A029003 | PGDB_C005652 | PGDB_AS000362 | View |
| GI50 | - | = | 9.3 | nM | - | — | BRAF | - | A375 | AU2022290851A1 | PGDB_A059816 | PGDB_C005652 | PGDB_AS000079 | View |
| DC50 | - | = | 14.55 | nM | - | — | BRAF | - | A375.10 | AU2022290851A1 | PGDB_A061752 | PGDB_C005652 | PGDB_AS001308 | View |
| GI50 | - | = | 55 | nM | - | — | BRAF | - | A375-NRASQ61K | AU2022290851A1 | PGDB_A070963 | PGDB_C005652 | PGDB_AS001149 | View |