PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cc(-c2ccc(-c3cn(C4CCC(=O)NC4=O)c(=O)o3)c(F)c2)nc(N)c1C

Compound summary

Compound IDPGDB_C009144

FormulaC21H19FN4O4

Molecular weight410.405

InChIKeyPKEKMIKJWMHBLO-UHFFFAOYSA-N

Physicochemical properties

Exact mass410.139

RDKit cLogP2.49

TPSA120.2

HBD / HBA2 / 7

Rotatable bonds3

Heavy atoms30

Hetero atoms9

Rings / aromatic4 / 3

Fraction Csp30.24

Formal charge0

Fragments1

Activity compounds and values

Activity records

22 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	=	13.6	nM	-	—	IKZF2	-	Jurkat	US20250129061A1	PGDB_A013686	PGDB_C009144	PGDB_AS001143	View
Dmax	-	=	73	%	-	-	IKZF4	-	-	US20250129061A1	PGDB_A017317	PGDB_C009144	PGDB_AS001833	View
DC50	-	=	4915	nM	-	—	IKZF3	-	Jurkat	US20250129061A1	PGDB_A020520	PGDB_C009144	PGDB_AS000744	View
Dmax	-	=	77	%	-	-	IKZF3	-	-	US20250129061A1	PGDB_A029872	PGDB_C009144	PGDB_AS001745	View
Dmax	-	=	74	%	Concentration context: titrated doses of compound	24 h	IKZF1	-	-	US20250129061A1	PGDB_A030360	PGDB_C009144	PGDB_AS001411	View
DC50	-	=	5466	nM	-	—	IKZF1	-	-	US20250129061A1	PGDB_A030478	PGDB_C009144	PGDB_AS000654	View
DC50	-	=	5.2	nM	-	—	IKZF2	-	-	US20250129061A1	PGDB_A036375	PGDB_C009144	PGDB_AS002052	View
DC50	-	=	1076	nM	-	—	IKZF1	-	Jurkat	US20250129061A1	PGDB_A037631	PGDB_C009144	PGDB_AS002138	View
Dmax	-	=	83	%	-	13 d	IKZF2	-	-	US20250129061A1	PGDB_A039204	PGDB_C009144	PGDB_AS001547	View
DC50	-	=	19	nM	-	—	IKZF3	-	-	US20250129061A1	PGDB_A040430	PGDB_C009144	PGDB_AS001957	View
Dmax	-	=	55	%	-	20 h	IKZF1	-	-	US20250129061A1	PGDB_A049405	PGDB_C009144	PGDB_AS002384	View
Dmax	-	=	73	%	Concentration context: titrated doses	13 d	IKZF4	-	-	US20250129061A1	PGDB_A056881	PGDB_C009144	PGDB_AS000732	View
DC50	-	=	1.5	nM	-	—	IKZF4	-	-	US20250129061A1	PGDB_A059874	PGDB_C009144	PGDB_AS002356	View
Dmax	-	=	94	%	-	72 h	IKZF2	-	Jurkat	US20250129061A1	PGDB_A061832	PGDB_C009144	PGDB_AS001285	View
Dmax	-	=	83	%	-	-	IKZF2	-	-	US20250129061A1	PGDB_A065434	PGDB_C009144	PGDB_AS001318	View
Dmax	-	=	99	%	-	20 h	IKZF2	-	-	US20250129061A1	PGDB_A067517	PGDB_C009144	PGDB_AS000813	View
DC50	-	=	102	nM	-	—	IKZF1	-	-	US20250129061A1	PGDB_A069941	PGDB_C009144	PGDB_AS000255	View
Dmax	-	=	54	%	-	72 h	IKZF3	-	Jurkat	US20250129061A1	PGDB_A070780	PGDB_C009144	PGDB_AS001493	View
Dmax	-	=	66	%	-	72 h	IKZF1	-	Jurkat	US20250129061A1	PGDB_A072766	PGDB_C009144	PGDB_AS000608	View
DC50	-	=	85	nM	-	—	IKZF2	-	-	US20250129061A1	PGDB_A072876	PGDB_C009144	PGDB_AS000731	View

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