PatGlueDB | Molecular Glue Patent Bioactivity Database

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2D structure

2D structure for PGDB_C009603

Cc1nc2cccc(N)c2cc1C1CCC(=O)NC1=O

Compound summary

Compound IDPGDB_C009603

FormulaC15H15N3O2

Molecular weight269.304

InChIKeyQDSCVODHGXABJE-UHFFFAOYSA-N

Physicochemical properties

Exact mass269.1164

RDKit cLogP1.65

TPSA85.1

HBD / HBA2 / 4

Rotatable bonds1

Heavy atoms20

Hetero atoms5

Rings / aromatic3 / 2

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

Structure		Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
	Ki	-	=	1-5	uM	-	—	CRBN	CRBN	-	WO2022146151A1	PGDB_A008671	PGDB_C009603	PGDB_AS002364	View
	% Degradation	-	>	25	%	1 uM	24 h	IKZF3	-	NCI-H929	WO2022146151A1	PGDB_A011324	PGDB_C009603	PGDB_AS001915	View
	% Degradation	-	=	75-100	%	10 uM	24 h	IKZF1	-	NCI-H929	WO2022146151A1	PGDB_A011985	PGDB_C009603	PGDB_AS001123	View
	% Cell viability	-	=	61.2	%	2 uM	72 h	-	-	NCI-H929	WO2022146151A1	PGDB_A039625	PGDB_C009603	PGDB_AS001633	View
	% Cell viability	-	=	47.5	%	13 uM	72 h	-	-	NCI-H929	WO2022146151A1	PGDB_A040597	PGDB_C009603	PGDB_AS000774	View
	% Degradation	-	=	26-74	%	1 uM	24 h	IKZF1	-	NCI-H929	WO2022146151A1	PGDB_A042995	PGDB_C009603	PGDB_AS000181	View
	% Degradation	-	>	25	%	1 uM	24 h	IKZF3	-	NCI-H929	WO2022146151A1	PGDB_A049472	PGDB_C009603	PGDB_AS001368	View
	% Degradation	-	>=	75	%	20 uM	24 h	IKZF3	CRBN	NCI-H929	WO2022146151A1	PGDB_A052220	PGDB_C009603	PGDB_AS001330	View
	% Degradation	-	>=	75	%	10 uM	24 h	IKZF3	-	NCI-H929	WO2022146151A1	PGDB_A057161	PGDB_C009603	PGDB_AS001803	View
	% Degradation	-	=	75-100	%	20 uM	24 h	IKZF1	CRBN	NCI-H929	WO2022146151A1	PGDB_A069932	PGDB_C009603	PGDB_AS000759	View
	% Cell viability	-	=	32.9	%	50 uM	72 h	-	-	NCI-H929	WO2022146151A1	PGDB_A074013	PGDB_C009603	PGDB_AS001930	View

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