PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2C(=O)c3ccc(CNC45CC6CC(CC(O)(C6)C4)C5)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014260

FormulaC23H26N4O5

Molecular weight438.484

InChIKeyQMDUBVZJDZAOSZ-UHFFFAOYSA-N

Physicochemical properties

Exact mass438.1903

RDKit cLogP1.31

TPSA119

HBD / HBA3 / 6

Rotatable bonds4

Heavy atoms32

Hetero atoms9

Rings / aromatic7 / 1

Fraction Csp30.57

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A018708	PGDB_C014260	PGDB_AS001967	View
% Inhibition	-	=	15-18	%	10 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A021099	PGDB_C014260	PGDB_AS002156	View
% Inhibition	-	=	10-15	%	10 nM	-	-	-	H2228	WO2024245444A1	PGDB_A023653	PGDB_C014260	PGDB_AS001356	View
% Inhibition	-	=	10-15	%	10 nM	-	-	-	H292	WO2024245444A1	PGDB_A026334	PGDB_C014260	PGDB_AS001605	View
% Inhibition	-	=	25-30	%	500 nM	-	-	-	H2228	WO2024245444A1	PGDB_A034483	PGDB_C014260	PGDB_AS000051	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A035731	PGDB_C014260	PGDB_AS000969	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A037035	PGDB_C014260	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A044068	PGDB_C014260	PGDB_AS001137	View
% Inhibition	-	=	25-40	%	500 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A045747	PGDB_C014260	PGDB_AS002131	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A056161	PGDB_C014260	PGDB_AS001444	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A067502	PGDB_C014260	PGDB_AS000339	View
% Inhibition	-	=	20-40	%	500 nM	-	-	-	H292	WO2024245444A1	PGDB_A074496	PGDB_C014260	PGDB_AS000415	View

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