PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1csc2ncnc(N3CCN(Cc4ccc5c(c4)C(=O)N(N4CCC(=O)NC4=O)C5=O)CC3)c12

Compound summary

Compound IDPGDB_C014308

FormulaC24H23N7O4S

Molecular weight505.56

InChIKeyOCODAUCFRXSXDG-UHFFFAOYSA-N

Physicochemical properties

Exact mass505.1532

RDKit cLogP1.77

TPSA119

HBD / HBA1 / 9

Rotatable bonds4

Heavy atoms36

Hetero atoms12

Rings / aromatic6 / 3

Fraction Csp30.33

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A007646	PGDB_C014308	PGDB_AS001967	View
% Inhibition	-	=	18-25	%	500 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A015241	PGDB_C014308	PGDB_AS002131	View
% Inhibition	-	=	20-40	%	500 nM	-	-	-	H292	WO2024245444A1	PGDB_A022135	PGDB_C014308	PGDB_AS000415	View
% Inhibition	-	=	20-25	%	500 nM	-	-	-	H2228	WO2024245444A1	PGDB_A026610	PGDB_C014308	PGDB_AS000051	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A032726	PGDB_C014308	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A039616	PGDB_C014308	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A042213	PGDB_C014308	PGDB_AS001137	View
% Inhibition	-	=	20-25	%	10 nM	-	-	-	H2228	WO2024245444A1	PGDB_A043519	PGDB_C014308	PGDB_AS001356	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A064814	PGDB_C014308	PGDB_AS002298	View
% Inhibition	-	=	20-40	%	10 nM	-	-	-	H292	WO2024245444A1	PGDB_A065155	PGDB_C014308	PGDB_AS001605	View
% Inhibition	-	=	15-18	%	10 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A071784	PGDB_C014308	PGDB_AS002156	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A075479	PGDB_C014308	PGDB_AS000969	View

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