PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC(C)c1cc2c(N3CCN(Cc4ccc5c(c4)C(=O)N(N4CCC(=O)NC4=O)C5=O)CC3)ncnc2s1

Compound summary

Compound IDPGDB_C014309

FormulaC26H27N7O4S

Molecular weight533.614

InChIKeyKCIBPJWOWPVZIB-UHFFFAOYSA-N

Physicochemical properties

Exact mass533.1845

RDKit cLogP2.59

TPSA119

HBD / HBA1 / 9

Rotatable bonds5

Heavy atoms38

Hetero atoms12

Rings / aromatic6 / 3

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A016820	PGDB_C014309	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A017306	PGDB_C014309	PGDB_AS001137	View
% Inhibition	-	=	20-25	%	10 nM	-	-	-	H2228	WO2024245444A1	PGDB_A029499	PGDB_C014309	PGDB_AS001356	View
% Inhibition	-	=	15-20	%	10 nM	-	-	-	H292	WO2024245444A1	PGDB_A032360	PGDB_C014309	PGDB_AS001605	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A034398	PGDB_C014309	PGDB_AS000339	View
% Inhibition	-	=	20-25	%	500 nM	-	-	-	H2228	WO2024245444A1	PGDB_A044023	PGDB_C014309	PGDB_AS000051	View
% Inhibition	-	=	40-60	%	10 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A062482	PGDB_C014309	PGDB_AS001519	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A065710	PGDB_C014309	PGDB_AS000969	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A066187	PGDB_C014309	PGDB_AS001967	View
% Inhibition	-	=	60-80	%	500 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A069014	PGDB_C014309	PGDB_AS000199	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A072186	PGDB_C014309	PGDB_AS001444	View
% Inhibition	-	=	15-20	%	500 nM	-	-	-	H292	WO2024245444A1	PGDB_A077398	PGDB_C014309	PGDB_AS000415	View

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