PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1sc2ncnc(N3CCN(Cc4ccc5c(c4)C(=O)N(N4CCC(=O)NC4=O)C5=O)CC3)c2c1C

Compound summary

Compound IDPGDB_C014310

FormulaC25H25N7O4S

Molecular weight519.587

InChIKeySQTZADIDKPITPN-UHFFFAOYSA-N

Physicochemical properties

Exact mass519.1689

RDKit cLogP2.08

TPSA119

HBD / HBA1 / 9

Rotatable bonds4

Heavy atoms37

Hetero atoms12

Rings / aromatic6 / 3

Fraction Csp30.36

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A009239	PGDB_C014310	PGDB_AS001137	View
% Inhibition	-	=	20-40	%	10 nM	-	-	-	H292	WO2024245444A1	PGDB_A011039	PGDB_C014310	PGDB_AS001605	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A027850	PGDB_C014310	PGDB_AS000969	View
% Inhibition	-	=	25-40	%	500 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A028858	PGDB_C014310	PGDB_AS002131	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A044825	PGDB_C014310	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A050350	PGDB_C014310	PGDB_AS000339	View
% Inhibition	-	=	20-40	%	500 nM	-	-	-	H292	WO2024245444A1	PGDB_A059304	PGDB_C014310	PGDB_AS000415	View
% Inhibition	-	=	30-40	%	10 nM	-	-	-	H2228	WO2024245444A1	PGDB_A060161	PGDB_C014310	PGDB_AS001356	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A066375	PGDB_C014310	PGDB_AS001967	View
% Inhibition	-	=	25-40	%	10 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A066804	PGDB_C014310	PGDB_AS002156	View
% Inhibition	-	=	25-30	%	500 nM	-	-	-	H2228	WO2024245444A1	PGDB_A069428	PGDB_C014310	PGDB_AS000051	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A072046	PGDB_C014310	PGDB_AS002298	View

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