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Compound
PGDB_C014317
9 activity records2 related patents
2D structure
O=C1CCN(N2C(=O)c3ccc(CN4CCN(c5nc6c(c(N7CCOCC7)n5)SCC6)CC4)cc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | CSNK1A1 | - | - | WO2024245444A1 | PGDB_A014716 | PGDB_C014317 | PGDB_AS000339 | View |
| % Inhibition | - | = | 20-40 | % | 500 nM | - | - | - | H292 | WO2024245444A1 | PGDB_A019501 | PGDB_C014317 | PGDB_AS000415 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF2 | - | - | WO2024245444A1 | PGDB_A019740 | PGDB_C014317 | PGDB_AS002298 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | WEE1 | - | - | WO2024245444A1 | PGDB_A024635 | PGDB_C014317 | PGDB_AS001444 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF1 | - | - | WO2024245444A1 | PGDB_A033259 | PGDB_C014317 | PGDB_AS000969 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | GSPT1 | - | - | WO2024245444A1 | PGDB_A043991 | PGDB_C014317 | PGDB_AS001137 | View |
| IC50 | - | = | 1.5-1.9 | uM | - | — | CRBN | CRBN | - | WO2025016359A1 | PGDB_A045438 | PGDB_C014317 | PGDB_AS001897 | View |
| % Inhibition | - | = | 15-20 | % | 10 nM | - | - | - | H292 | WO2024245444A1 | PGDB_A070118 | PGDB_C014317 | PGDB_AS001605 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF3 | - | - | WO2024245444A1 | PGDB_A075572 | PGDB_C014317 | PGDB_AS001967 | View |