PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CCC(c5cccc(F)c5F)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014325

FormulaC24H24F2N4O3

Molecular weight454.477

InChIKeyFEIIMUKQXBMEES-UHFFFAOYSA-N

Physicochemical properties

Exact mass454.1816

RDKit cLogP3.16

TPSA73

HBD / HBA1 / 4

Rotatable bonds4

Heavy atoms33

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A010662	PGDB_C014325	PGDB_AS001444	View
% Inhibition	-	=	18-25	%	10 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A025401	PGDB_C014325	PGDB_AS001519	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A038823	PGDB_C014325	PGDB_AS002298	View
% Inhibition	-	=	20-25	%	500 nM	-	-	-	H2228	WO2024245444A1	PGDB_A051291	PGDB_C014325	PGDB_AS000051	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A055362	PGDB_C014325	PGDB_AS000969	View
% Inhibition	-	=	60-80	%	500 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A057351	PGDB_C014325	PGDB_AS000199	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A060228	PGDB_C014325	PGDB_AS001137	View
% Inhibition	-	=	18-25	%	10 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A061963	PGDB_C014325	PGDB_AS002156	View
% Inhibition	-	=	20-25	%	10 nM	-	-	-	H2228	WO2024245444A1	PGDB_A062589	PGDB_C014325	PGDB_AS001356	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A065791	PGDB_C014325	PGDB_AS001967	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A074094	PGDB_C014325	PGDB_AS000339	View
% Inhibition	-	=	25-40	%	500 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A076408	PGDB_C014325	PGDB_AS002131	View

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