PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ccc(C2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)s1

Compound summary

Compound IDPGDB_C019265

FormulaC24H27N3O3S

Molecular weight437.565

InChIKeyOFMCOBHGENBMCZ-UHFFFAOYSA-N

Physicochemical properties

Exact mass437.1773

RDKit cLogP3.2

TPSA69.7

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms31

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.46

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A009140	PGDB_C019265	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A013464	PGDB_C019265	PGDB_AS000700	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A014821	PGDB_C019265	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A015889	PGDB_C019265	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A034113	PGDB_C019265	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A049285	PGDB_C019265	PGDB_AS002547	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A058765	PGDB_C019265	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A064841	PGDB_C019265	PGDB_AS000593	View

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