PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CC=C(c5ccco5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019289

FormulaC23H23N3O4

Molecular weight405.454

InChIKeyQPLODITZAVWPGO-UHFFFAOYSA-N

Physicochemical properties

Exact mass405.1689

RDKit cLogP2.33

TPSA82.9

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms30

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A007165	PGDB_C019289	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A030711	PGDB_C019289	PGDB_AS002547	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A036243	PGDB_C019289	PGDB_AS001897	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A042672	PGDB_C019289	PGDB_AS001975	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A065639	PGDB_C019289	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A066162	PGDB_C019289	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A074238	PGDB_C019289	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A076999	PGDB_C019289	PGDB_AS000700	View

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