PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(c5nccc(Cl)c5Cl)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019306

FormulaC24H24Cl2N4O3

Molecular weight487.387

InChIKeyQHZODEITCZXGPT-UHFFFAOYSA-N

Physicochemical properties

Exact mass486.1225

RDKit cLogP3.53

TPSA82.6

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms33

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A015522	PGDB_C019306	PGDB_AS002547	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A023226	PGDB_C019306	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A038314	PGDB_C019306	PGDB_AS001760	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A041575	PGDB_C019306	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A047617	PGDB_C019306	PGDB_AS001647	View
IC50	-	=	500-1000	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A047676	PGDB_C019306	PGDB_AS000939	View
IC50	-	=	500-1000	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A049926	PGDB_C019306	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A067123	PGDB_C019306	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A068498	PGDB_C019306	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A074347	PGDB_C019306	PGDB_AS000700	View

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