PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5nc6c(c(N7CCOCC7)n5)SCC6)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019310

FormulaC28H33N7O4S

Molecular weight563.684

InChIKeyPRXVDVHBGMTONL-UHFFFAOYSA-N

Physicochemical properties

Exact mass563.2315

RDKit cLogP1.04

TPSA111.2

HBD / HBA1 / 10

Rotatable bonds5

Heavy atoms40

Hetero atoms12

Rings / aromatic7 / 2

Fraction Csp30.54

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A010223	PGDB_C019310	PGDB_AS001897	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A011403	PGDB_C019310	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A012520	PGDB_C019310	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A049827	PGDB_C019310	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A070724	PGDB_C019310	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A073094	PGDB_C019310	PGDB_AS002547	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A073316	PGDB_C019310	PGDB_AS001647	View

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