PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1sc2ncnc(N3CCN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c2c1C

Compound summary

Compound IDPGDB_C019318

FormulaC26H28N6O3S

Molecular weight504.616

InChIKeyTVFGKIGYMJHMOL-UHFFFAOYSA-N

Physicochemical properties

Exact mass504.1944

RDKit cLogP2.39

TPSA98.7

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms36

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A007111	PGDB_C019318	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A014117	PGDB_C019318	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A017206	PGDB_C019318	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A020546	PGDB_C019318	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A027357	PGDB_C019318	PGDB_AS001647	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A031500	PGDB_C019318	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A037714	PGDB_C019318	PGDB_AS002547	View

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