PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1nc(C2=CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)c2ccsc2n1

Compound summary

Compound IDPGDB_C019329

FormulaC26H25N5O3S

Molecular weight487.585

InChIKeyFRGOFVMDQGIRQH-UHFFFAOYSA-N

Physicochemical properties

Exact mass487.1678

RDKit cLogP3.05

TPSA95.5

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms35

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A008826	PGDB_C019329	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A013257	PGDB_C019329	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A016681	PGDB_C019329	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A017440	PGDB_C019329	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A020926	PGDB_C019329	PGDB_AS002465	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A027302	PGDB_C019329	PGDB_AS001897	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A037541	PGDB_C019329	PGDB_AS001647	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A044033	PGDB_C019329	PGDB_AS000537	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A049588	PGDB_C019329	PGDB_AS001975	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A057036	PGDB_C019329	PGDB_AS000939	View

Rows per pagePage 1 of 1 · 10 recordsGo to page