PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5nc(N6CCOCC6)nc6ccsc56)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019355

FormulaC28H31N7O4S

Molecular weight561.668

InChIKeyWNNJHPQDYUNFDR-UHFFFAOYSA-N

Physicochemical properties

Exact mass561.2158

RDKit cLogP1.61

TPSA111.2

HBD / HBA1 / 10

Rotatable bonds5

Heavy atoms40

Hetero atoms12

Rings / aromatic7 / 3

Fraction Csp30.46

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A009852	PGDB_C019355	PGDB_AS000593	View
IC50	-	=	10-50	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A017996	PGDB_C019355	PGDB_AS001138	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A027440	PGDB_C019355	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A055913	PGDB_C019355	PGDB_AS002465	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A063486	PGDB_C019355	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A063688	PGDB_C019355	PGDB_AS002547	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A066411	PGDB_C019355	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A076636	PGDB_C019355	PGDB_AS000700	View

Rows per pagePage 1 of 1 · 8 recordsGo to page