PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CC5CCC4CN5c4cccc(Cl)c4Cl)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019361

FormulaC26H26Cl2N4O3

Molecular weight513.425

InChIKeyYJVKKZFYCYSCJW-UHFFFAOYSA-N

Physicochemical properties

Exact mass512.1382

RDKit cLogP3.61

TPSA73

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms35

Hetero atoms9

Rings / aromatic7 / 2

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A047347	PGDB_C019361	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A050100	PGDB_C019361	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A050835	PGDB_C019361	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A053486	PGDB_C019361	PGDB_AS002547	View
IC50	-	=	10-50	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A056923	PGDB_C019361	PGDB_AS001138	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A069221	PGDB_C019361	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A070723	PGDB_C019361	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A077177	PGDB_C019361	PGDB_AS001647	View

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