PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CCN(c5cccc6sccc56)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019374

FormulaC26H24N4O4S

Molecular weight488.569

InChIKeyREBSWQHZTUBISR-UHFFFAOYSA-N

Physicochemical properties

Exact mass488.1518

RDKit cLogP2.62

TPSA90

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms35

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.31

Formal charge0

Fragments1

Activity compounds and values

Activity records

9 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A014125	PGDB_C019374	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A016804	PGDB_C019374	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A021213	PGDB_C019374	PGDB_AS001647	View
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A024329	PGDB_C019374	PGDB_AS001138	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A044892	PGDB_C019374	PGDB_AS000593	View
IC50	-	=	500-1000	nM	-	—	-	-	H1975	WO2025016359A1	PGDB_A054528	PGDB_C019374	PGDB_AS000559	View
IC50	-	=	100-500	nM	-	—	-	-	Jurkat	WO2025016359A1	PGDB_A055734	PGDB_C019374	PGDB_AS002351	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A065855	PGDB_C019374	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A073705	PGDB_C019374	PGDB_AS002547	View

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