PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CC=C(c5ncnc6sc7c(c56)CCCC7)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019384

FormulaC29H29N5O3S

Molecular weight527.65

InChIKeyNXMLYSADXHPTOR-UHFFFAOYSA-N

Physicochemical properties

Exact mass527.1991

RDKit cLogP3.62

TPSA95.5

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms38

Hetero atoms9

Rings / aromatic7 / 3

Fraction Csp30.41

Formal charge0

Fragments1

Activity compounds and values

Activity records

9 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A007617	PGDB_C019384	PGDB_AS001760	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A012257	PGDB_C019384	PGDB_AS001897	View
IC50	-	=	5-10	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A030234	PGDB_C019384	PGDB_AS001138	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A043162	PGDB_C019384	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A050936	PGDB_C019384	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A051790	PGDB_C019384	PGDB_AS000593	View
IC50	-	=	10-50	nM	-	—	-	-	TMD8	WO2025016359A1	PGDB_A053810	PGDB_C019384	PGDB_AS000019	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A065182	PGDB_C019384	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A067150	PGDB_C019384	PGDB_AS000700	View

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