PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1nc(N2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)c2c3c(sc2n1)CCC3

Compound summary

Compound IDPGDB_C019403

FormulaC28H28N6O4S

Molecular weight544.637

InChIKeyXTOQMFOTVYDHNM-UHFFFAOYSA-N

Physicochemical properties

Exact mass544.1893

RDKit cLogP2.21

TPSA115.8

HBD / HBA1 / 9

Rotatable bonds4

Heavy atoms39

Hetero atoms11

Rings / aromatic7 / 3

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A008202	PGDB_C019403	PGDB_AS001647	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A027512	PGDB_C019403	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A043254	PGDB_C019403	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A046758	PGDB_C019403	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A052711	PGDB_C019403	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A060751	PGDB_C019403	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A074318	PGDB_C019403	PGDB_AS001760	View

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