PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ccc(N2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)s1

Compound summary

Compound IDPGDB_C019406

FormulaC23H24N4O4S

Molecular weight452.536

InChIKeyFFBDCHVEQLFLAT-UHFFFAOYSA-N

Physicochemical properties

Exact mass452.1518

RDKit cLogP1.78

TPSA90

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms32

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.39

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A007177	PGDB_C019406	PGDB_AS001647	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A013135	PGDB_C019406	PGDB_AS000593	View
IC50	-	=	1.5-1.9	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A019647	PGDB_C019406	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A025333	PGDB_C019406	PGDB_AS002547	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A028348	PGDB_C019406	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A046482	PGDB_C019406	PGDB_AS000700	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A063355	PGDB_C019406	PGDB_AS001760	View

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