PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC(C)c1cc2c(C3=CCN(Cc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)ncnc2s1

Compound summary

Compound IDPGDB_C019467

FormulaC28H27N5O4S

Molecular weight529.622

InChIKeyADVARVBXBRKQIQ-UHFFFAOYSA-N

Physicochemical properties

Exact mass529.1784

RDKit cLogP3.51

TPSA112.6

HBD / HBA1 / 8

Rotatable bonds5

Heavy atoms38

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.36

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A008999	PGDB_C019467	PGDB_AS001138	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A013251	PGDB_C019467	PGDB_AS001760	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A022210	PGDB_C019467	PGDB_AS001897	View
IC50	-	=	50-100	nM	-	—	-	-	Jurkat	WO2025016359A1	PGDB_A029641	PGDB_C019467	PGDB_AS002351	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A030314	PGDB_C019467	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A038051	PGDB_C019467	PGDB_AS000700	View
IC50	-	=	10-50	nM	-	—	-	-	CCRF-CEM	WO2025016359A1	PGDB_A051248	PGDB_C019467	PGDB_AS001127	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A057849	PGDB_C019467	PGDB_AS000593	View
IC50	-	=	10-50	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A060606	PGDB_C019467	PGDB_AS001504	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A063059	PGDB_C019467	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A064461	PGDB_C019467	PGDB_AS002465	View
IC50	-	=	10-50	nM	-	—	-	-	MOLT-4	WO2025016359A1	PGDB_A070038	PGDB_C019467	PGDB_AS000277	View

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