PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1sc2ncnc(C3=CCN(Cc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)c2c1C

Compound summary

Compound IDPGDB_C019468

FormulaC27H25N5O4S

Molecular weight515.595

InChIKeyATKICMUDVNRFHM-UHFFFAOYSA-N

Physicochemical properties

Exact mass515.1627

RDKit cLogP3

TPSA112.6

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms37

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.33

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A008472	PGDB_C019468	PGDB_AS002465	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A013580	PGDB_C019468	PGDB_AS001897	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A026176	PGDB_C019468	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A033706	PGDB_C019468	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A040072	PGDB_C019468	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A041590	PGDB_C019468	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A065039	PGDB_C019468	PGDB_AS000593	View

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