PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CC=C(c5ncnc6sc7c(c56)CCCC7)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019473

FormulaC29H27N5O4S

Molecular weight541.633

InChIKeyIAYJXFVKFSNLCH-UHFFFAOYSA-N

Physicochemical properties

Exact mass541.1784

RDKit cLogP3.26

TPSA112.6

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms39

Hetero atoms10

Rings / aromatic7 / 3

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A007199	PGDB_C019473	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A008059	PGDB_C019473	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A024560	PGDB_C019473	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A029583	PGDB_C019473	PGDB_AS001760	View
IC50	-	=	1.5-1.9	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A033690	PGDB_C019473	PGDB_AS001897	View
IC50	-	=	10-50	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A034126	PGDB_C019473	PGDB_AS001504	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A039529	PGDB_C019473	PGDB_AS002465	View
IC50	-	=	100-500	nM	-	—	-	-	MOLT-4	WO2025016359A1	PGDB_A045525	PGDB_C019473	PGDB_AS000277	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A064656	PGDB_C019473	PGDB_AS001647	View
IC50	-	=	100-500	nM	-	—	-	-	CCRF-CEM	WO2025016359A1	PGDB_A066253	PGDB_C019473	PGDB_AS001127	View
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A077039	PGDB_C019473	PGDB_AS001138	View

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