PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CC=C(c5nccc(Cl)c5Cl)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019506

FormulaC24H20Cl2N4O4

Molecular weight499.354

InChIKeyKPGDNQOIIOFDHM-UHFFFAOYSA-N

Physicochemical properties

Exact mass498.0862

RDKit cLogP3.08

TPSA99.7

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms34

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	100-500	nM	-	—	-	-	MOLT-4	WO2025016359A1	PGDB_A009121	PGDB_C019506	PGDB_AS000277	View
IC50	-	=	100-500	nM	-	—	-	-	Jurkat	WO2025016359A1	PGDB_A019427	PGDB_C019506	PGDB_AS002351	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A020692	PGDB_C019506	PGDB_AS001897	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A025346	PGDB_C019506	PGDB_AS002547	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A027351	PGDB_C019506	PGDB_AS000593	View
IC50	-	=	100-500	nM	-	—	-	-	CCRF-CEM	WO2025016359A1	PGDB_A028186	PGDB_C019506	PGDB_AS001127	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A028443	PGDB_C019506	PGDB_AS000700	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A034416	PGDB_C019506	PGDB_AS001647	View
IC50	-	=	10-50	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A045907	PGDB_C019506	PGDB_AS001504	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A052234	PGDB_C019506	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A073112	PGDB_C019506	PGDB_AS002465	View
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A074715	PGDB_C019506	PGDB_AS001138	View

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