PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CC(=C5CCOc6cc(F)ccc65)C4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019527

FormulaC26H22FN3O5

Molecular weight475.476

InChIKeyFGSJAAAWJQDPSZ-UHFFFAOYSA-N

Physicochemical properties

Exact mass475.1543

RDKit cLogP2.28

TPSA96

HBD / HBA1 / 6

Rotatable bonds3

Heavy atoms35

Hetero atoms9

Rings / aromatic6 / 2

Fraction Csp30.31

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	20-30	%	500 nM	-	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A013685	PGDB_C019527	PGDB_AS000281	View
% Inhibition	-	=	60-80	%	500 nM	-	IKZF3	-	Kasumi-1	WO2025016359A1	PGDB_A015128	PGDB_C019527	PGDB_AS000467	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A015355	PGDB_C019527	PGDB_AS000593	View
% Inhibition	-	=	10-15	%	10 nM	-	IKZF3	-	Kasumi-1	WO2025016359A1	PGDB_A024109	PGDB_C019527	PGDB_AS001962	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A027772	PGDB_C019527	PGDB_AS000700	View
% Inhibition	-	=	30-40	%	10 nM	-	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A030644	PGDB_C019527	PGDB_AS000133	View
% Inhibition	-	=	15-20	%	10 nM	-	IKZF3	-	CCRF-CEM	WO2025016359A1	PGDB_A041287	PGDB_C019527	PGDB_AS001627	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A043861	PGDB_C019527	PGDB_AS001647	View
% Inhibition	-	=	60-80	%	500 nM	-	IKZF3	-	CCRF-CEM	WO2025016359A1	PGDB_A048924	PGDB_C019527	PGDB_AS002504	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A064028	PGDB_C019527	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A068743	PGDB_C019527	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A077096	PGDB_C019527	PGDB_AS001760	View

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